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. 1973 Jul;8(1):4–7. doi: 10.1128/iai.8.1.4-7.1973

Metabolism of Rickettsia tsutsugamushi and Rickettsia rickettsi in Irradiated Host Cells

E Weiss 1, A E Green 1, R Grays 1, L M Newman 1
PMCID: PMC422800  PMID: 4198104

Abstract

The metabolism of Rickettsia tsutsugamushi (Gilliam strain) multiplying in irradiated L cells was investigated by methods involving the use of 14C-labeled substrates and cycloheximide, an inhibitor of eukaryotic metabolism. Cycloheximide-resistant amino acid and adenine incorporations were appreciably higher in infected than in uninfected cultures during the period from 3 to 5 or 6 days postinoculation. The metabolism of R. rickettsi was similarly studied in primary duck embryo cells, which are more susceptible to infection with this rickettsia than are L cells. A difference in cycloheximide-resistant activity between infected and uninfected cultures was also noted, but was small. This finding is attributed to the more limited growth of R. rickettsi.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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