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. 1973 Jul;8(1):105–109. doi: 10.1128/iai.8.1.105-109.1973

Altered Immune Functions in Hypercholesterolemic Monkeys

R H Fiser Jr a,1, J C Denniston a,2, V G McGann a, J Kaplan a,3, W H Adler III a,4, M D Kastello a, W R Beisel a,5
PMCID: PMC422817  PMID: 4198100

Abstract

Humoral and cellular immune responses to several antigens were compared in control and hypercholesterolemic groups of monkeys. Chronic hypercholesterolemia, with concomitant hyperphospholipidemia and hypotriglyceridemia, was produced experimentally by feeding monkeys a high-fat, high-cholesterol diet. When studied prior to infection, hypercholesterolemic monkeys exhibited impaired development of precipitating antibodies against ovalbumin, enhanced sensitivity to tuberculin antigen (stimulated apparently by mycobacterial components in complete Freund adjuvant), and an increased rate of clearance of colloidal carbon from blood. During pneumococcal infection the ability of neutrophiles from hypercholesterolemic monkeys to reduce nitroblue tetrazolium dye showed an increase greater than that of control monkeys; both groups exhibited increased but comparable final clearance rates of colloidal carbon, although the increment of increase was smaller in hypercholesterolemic monkeys.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong M. L., Connor W. E., Warner E. D. Xanthomatosis in rhesus monkeys fed a hypercholesterolemic diet. Arch Pathol. 1967 Sep;84(3):227–237. [PubMed] [Google Scholar]
  2. Beisel W. R., Fiser R. H., Jr Lipid metabolism during infectious illness. Am J Clin Nutr. 1970 Aug;23(8):1069–1079. doi: 10.1093/ajcn/23.8.1069. [DOI] [PubMed] [Google Scholar]
  3. DAY A. J. THE MACROPHAGE SYSTEM, LIPID METABOLISM AND ATHEROSCLEROSIS. J Atheroscler Res. 1964 Mar-Apr;4:117–130. doi: 10.1016/s0368-1319(64)80032-6. [DOI] [PubMed] [Google Scholar]
  4. DILUZIO N. R., WOOLES W. R. DEPRESSION OF PHAGOCYTIC ACTIVITY AND IMMUNE RESPONSE BY METHYL PALMITATE. Am J Physiol. 1964 May;206:939–943. doi: 10.1152/ajplegacy.1964.206.5.939. [DOI] [PubMed] [Google Scholar]
  5. Feigin R. D., Shackelford P. G., Choi S. C. Prospective use of the nitroblue tetrazolium dye test in febrile disorders. J Pediatr. 1971 Dec;79(6):943–947. doi: 10.1016/s0022-3476(71)80188-9. [DOI] [PubMed] [Google Scholar]
  6. Fiser R. H., Denniston J. C., Kastello M. D., Rindsig R. B., Beisel W. R. Cholesterogenesis during acute infection in chronically hypercholesterolemic rhesus monkeys. Proc Soc Exp Biol Med. 1972 May;140(1):314–318. doi: 10.3181/00379727-140-36448. [DOI] [PubMed] [Google Scholar]
  7. Fiser R. H., Denniston J. C., Rindsic R. B., Beisel W. R. Effects of acute infection on cholesterogenesis in the rhesus monkey. Proc Soc Exp Biol Med. 1971 Nov;138(2):605–609. doi: 10.3181/00379727-138-35951. [DOI] [PubMed] [Google Scholar]
  8. Fiser R. H., Rollins J. B., Beisel W. R. Decreased resistance against infectious canine hepatitis in dogs fed a high-fat ration. Am J Vet Res. 1972 Apr;33(4):713–719. [PubMed] [Google Scholar]
  9. GORDON J., ROSE B., SEHON A. H. Detection of non-precipitating antibodies in sera of individuals allergic to ragweed pollen by an in vitro method. J Exp Med. 1958 Jul 1;108(1):37–51. doi: 10.1084/jem.108.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lees R. S., Fiser R. H., Jr, Beisel W. R., Bartelloni P. J. Effects of an experimental viral infection on plasma lipid and lipoprotein metabolism. Metabolism. 1972 Sep;21(9):825–833. doi: 10.1016/0026-0495(72)90005-4. [DOI] [PubMed] [Google Scholar]
  11. Newberne P. M., Young V. R., Gravlee J. F. Effects of caloric intake and infection on some aspects of protein metabolism in dogs. Br J Exp Pathol. 1969 Apr;50(2):172–180. [PMC free article] [PubMed] [Google Scholar]
  12. Park B. H., Fikrig S. M., Smithwick E. M. Infection and nitroblue-tetrazolium reduction by neutrophils. A diagnostic acid. Lancet. 1968 Sep 7;2(7567):532–534. doi: 10.1016/s0140-6736(68)92406-9. [DOI] [PubMed] [Google Scholar]
  13. STUART A. E., DAVIDSON A. E. EFFECT OF SIMPLE LIPIDS ON ANTIBODY FORMATION AFTER INJECTION OF FOREIGN RED CELLS. J Pathol Bacteriol. 1964 Apr;87:305–316. doi: 10.1002/path.1700870210. [DOI] [PubMed] [Google Scholar]
  14. Staab E. V., Normann S. J., Craig C. P. Alterations in reticuloendothelial function by infection with attenuated Venezuelan equine encephalitis (VEE) virus. J Reticuloendothel Soc. 1970 Oct;8(4):342–348. [PubMed] [Google Scholar]
  15. Tracey V. V., De N. C., Harper J. R. Obesity and respiratory infection in infants and young children. Br Med J. 1971 Jan 2;1(5739):16–18. doi: 10.1136/bmj.1.5739.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. WAGNER H. N., Jr, IIO M., HORNICK R. B. Studies of the reticuloendothelial system (RES). II. Changes in the phagocytic capacity of the RES in patients with certain infections. J Clin Invest. 1963 Mar;42:427–434. doi: 10.1172/JCI104730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Williams G., Newberne P. M. Effects of infection on selected clinical and biochemical parameters in dogs. Br J Exp Pathol. 1970 Jun;51(3):253–264. [PMC free article] [PubMed] [Google Scholar]

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