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. 1973 Aug;8(2):228–235. doi: 10.1128/iai.8.2.228-235.1973

Distribution by Serological Type of Group B Streptococci Isolated from a Variety of Clinical Material over a Five-Year Period (with Special Reference to Neonatal Sepsis and Meningitis)

Hazel W Wilkinson 1, R R Facklam 1, E C Wortham 1
PMCID: PMC422837  PMID: 4725698

Abstract

A total of 898 group B streptococci isolated from a wide variety of human clinical sources from July 1967 through June 1972 were typed by the Lancefield precipitin test. Only 11% of the strains were nontypable. Twenty-six percent of the group B strains were from respiratory sources, 22% were from cerebrospinal fluid (CSF) and blood, 13% were from the female genital tract, 12% were urine specimens, and the remaining 27% were from other varied sources. The clinical conditions reported for patients from whom these organisms were isolated included neonatal meningitis and sepsis, pharyngitis, urinary tract and female genital tract infections, and various skin and wound infections. Seventy percent of the CSF and blood cultures from patients with meningitis or sepsis, or both, were type III, whereas the overall percentage of this type was 32%. All but three CSF isolates were from patients under 2 years of age; the distribution of CSF isolates appeared to be the same for both sexes. In contrast, group B streptococci were isolated more frequently from the blood of males than from the blood of females. There were twice as many blood cultures from patients under 2 years of age than from those that were older.

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Selected References

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  1. Baker C. J., Barrett F. F., Gordon R. C., Yow M. D. Suppurative meningitis due to streptococci of Lancefield group B: a study of 33 infants. J Pediatr. 1973 Apr;82(4):724–729. doi: 10.1016/s0022-3476(73)80606-7. [DOI] [PubMed] [Google Scholar]
  2. Barton L. L., Feigin R. D., Lins R. Group B beta hemolytic streptococcal meningitis in infants. J Pediatr. 1973 Apr;82(4):719–723. doi: 10.1016/s0022-3476(73)80605-5. [DOI] [PubMed] [Google Scholar]
  3. Braunstein H., Tucker E. B., Gibson B. C. Identification and significance of Streptococcus agalactiae (Lancefield group B). Am J Clin Pathol. 1969 Feb;51(2):207–213. doi: 10.1093/ajcp/51.2.207. [DOI] [PubMed] [Google Scholar]
  4. Cayeux P. Infections néonatales à streptocoques du groupe B. Constatations etiologiques. A propos de 77 observations. Arch Fr Pediatr. 1972 Apr;29(4):391–396. [PubMed] [Google Scholar]
  5. EICKHOFF T. C., KLEIN J. O., DALY A. K., INGALL D., FINLAND M. NEONATAL SEPSIS AND OTHER INFECTIONS DUE TO GROUP B BETA-HEMOLYTIC STREPTOCOCCI. N Engl J Med. 1964 Dec 10;271:1221–1228. doi: 10.1056/NEJM196412102712401. [DOI] [PubMed] [Google Scholar]
  6. Feingold D. S., Stagg N. L., Kunz L. J. Extrarespiratory streptococcal infections. Importance of the various serologic groups. N Engl J Med. 1966 Aug 18;275(7):356–361. doi: 10.1056/NEJM196608182750704. [DOI] [PubMed] [Google Scholar]
  7. Finn P. D., Holden F. A. Observations and comments concerning the isolation of group B beta-hemolytic streptococci from human sources. Can Med Assoc J. 1970 Aug 1;103(3):249–252. [PMC free article] [PubMed] [Google Scholar]
  8. Franciosi R. A., Knostman J. D., Zimmerman R. A. Group B streptococcal neonatal and infant infections. J Pediatr. 1973 Apr;82(4):707–718. doi: 10.1016/s0022-3476(73)80604-3. [DOI] [PubMed] [Google Scholar]
  9. Freimer E. H. Type-specific polysaccharide antigens of group B streptococci. II. The chemical basis for serological specificity of the type II HCl antigen. J Exp Med. 1967 Mar 1;125(3):381–392. doi: 10.1084/jem.125.3.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HOOD M., JANNEY A., DAMERON G. Beta hemolytic streptococcus group B associated with problems of the perinatal period. Am J Obstet Gynecol. 1961 Oct;82:809–818. doi: 10.1016/s0002-9378(16)36146-4. [DOI] [PubMed] [Google Scholar]
  11. Harper I. A. The importance of group B streptococci as human pathogens in the British Isles. J Clin Pathol. 1971 Jul;24(5):438–441. doi: 10.1136/jcp.24.5.438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Jelínková J., Neubauer M., Duben J. Group B streptococci in human pathology. Zentralbl Bakteriol Orig. 1970;214(3):450–457. [PubMed] [Google Scholar]
  13. Kvittingen J. Beta-haemolytic Streptococcus group B causing neonatal meningitis. Acta Pathol Microbiol Scand. 1968;74(1):143–144. doi: 10.1111/j.1699-0463.1968.tb03465.x. [DOI] [PubMed] [Google Scholar]
  14. Lancefield R. C., Freimer E. H. Type-specific polysaccharide antigens of group B streptococci. J Hyg (Lond) 1966 Jun;64(2):191–203. doi: 10.1017/s0022172400040456. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. MacKnight J. F., Ellis P. J., Jensen K. A., Franz B. Group B streptococci in neonatal deaths. Appl Microbiol. 1969 Jun;17(6):926–926. doi: 10.1128/am.17.6.926-926.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Maher E., Irwin R. C. Group B streptococcal infection in infancy: a case report and review. Pediatrics. 1966 Oct;38(4):659–661. [PubMed] [Google Scholar]
  17. McCracken G. H., Jr The rate of bacteriologic response to antimicrobial therapy in neonatal meningitis. Am J Dis Child. 1972 Jun;123(6):547–553. doi: 10.1001/archpedi.1972.02110120071004. [DOI] [PubMed] [Google Scholar]
  18. NYHAN W. L., FOUSEK M. D. Septicemia of the newborn. Pediatrics. 1958 Aug;22(2):268–278. [PubMed] [Google Scholar]
  19. Overall J. C., Jr Neonatal bacterial meningitis. Analysis of predisposing factors and outcome compared with matched control subjects. J Pediatr. 1970 Apr;76(4):499–511. doi: 10.1016/s0022-3476(70)80399-7. [DOI] [PubMed] [Google Scholar]
  20. PATTISON I. H., MATTHEWS P. R., HOWELL D. G. The type classification of group-B streptococci, with special reference to bovine strains apparently lacking in type polysaccharide. J Pathol Bacteriol. 1955 Jan-Apr;69(1-2):51–60. [PubMed] [Google Scholar]
  21. PATTISON I. H., MATTHEWS P. R., MAXTED W. R. Type classification by Lancefield's precipitin method of human and bovine group-B streptococci isolated in Britain. J Pathol Bacteriol. 1955 Jan-Apr;69(1-2):43–50. doi: 10.1002/path.1700690108. [DOI] [PubMed] [Google Scholar]
  22. Riley H. D., Jr Neonatal meningitis. J Infect Dis. 1972 Apr;125(4):420–425. doi: 10.1093/infdis/125.4.420. [DOI] [PubMed] [Google Scholar]
  23. Rogers K. B. Neonaal meningitis and pneumonia due to Lancefield group B streptococci. Arch Dis Child. 1970 Feb;45(239):147–147. doi: 10.1136/adc.45.239.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Sander C., Steinitz H., Lösel I. Meningitis und Sepsis im Neugeborenenalter durch B-Streptokokken (Streptococcus agalactiae) Monatsschr Kinderheilkd. 1970 Dec;118(12):640–643. [PubMed] [Google Scholar]
  25. VANPEENEN P. F., CANNON R. E., SEIBERT D. J. GROUP B BETA-HEMOLYTIC STREPTOCOCCI CAUSING FATAL MENINGITIS IN AN INFANT. Mil Med. 1965 Jan;130:65–67. [PubMed] [Google Scholar]
  26. Wheeler W. E. Nonepidemic infections peculiar to the gravid state. Am J Dis Child. 1966 Sep;112(3):175–176. doi: 10.1001/archpedi.1966.02090120043001. [DOI] [PubMed] [Google Scholar]
  27. Wilkinson H. W. Comparison of streptococcal R antigens. Appl Microbiol. 1972 Oct;24(4):669–670. doi: 10.1128/am.24.4.669-670.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Wilkinson H. W., Eagon R. G. Type-specific antigens of group B type Ic streptococci. Infect Immun. 1971 Nov;4(5):596–604. doi: 10.1128/iai.4.5.596-604.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Wilkinson H. W., Moody M. D. Serological relationships of type I antigens of group B streptococci. J Bacteriol. 1969 Feb;97(2):629–634. doi: 10.1128/jb.97.2.629-634.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Winterbauer R. H., Fortuine R., Eickhoff T. C. Unusual occurrence of neonatal meningitis due to group B beta-hemolytic streptococci. Pediatrics. 1966 Oct;38(4):661–662. [PubMed] [Google Scholar]
  31. ZIAI M., HAGGERTY R. J. Neonatal meningitis. N Engl J Med. 1958 Aug 14;259(7):314–320. doi: 10.1056/NEJM195808142590702. [DOI] [PubMed] [Google Scholar]
  32. Zahradnický J., Lukesová M., Kronus R., Jelínková J., Hejda V., Valchová M., Turková S. An unusual case of infection caused by a group B streptococcus. J Hyg Epidemiol Microbiol Immunol. 1972;16(1):21–27. [PubMed] [Google Scholar]

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