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. 1973 Nov;8(5):736–742. doi: 10.1128/iai.8.5.736-742.1973

Virulence of Six Strains of Mycobacterium bovis (BCG) in Mice

Neal A Sher 1,2, Sotiros D Chaparas 1,2, Jack Pearson 1,2, Michael Chirigos 1,2
PMCID: PMC422920  PMID: 4584050

Abstract

The abilities of six strains of Mycobacterium bovis strain BCG to replicate in vivo and to cause spleen enlargement in the CDF1 male mouse were compared. The strains were grown in synthetic medium and harvested soon after complete pellicles were produced on liquid medium. In addition, two freeze-dried commercially available preparations were tested. The comparisons were made on the basis of injecting equal numbers of colony-forming units. Strain differences were marked. The Brazil strain was most effective in stimulating spleen enlargement, and the Japan strain was the least effective. This correlated with the number of colony-forming units isolated from the spleen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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