Abstract
We studied the effect of the same genetic but different environmental factors on total immunoglobulin and specific antibody levels in twins reared apart. Sera were analyzed from 26 monozygotic (MZ) and 10 dizygotic (DZ) twin pairs, who were separated on average 2 mo after birth and reared apart. Total IgM, IgG, and IgA were measured by single radial diffusion. Specific antibodies of each isotype to tetanus toxoid, and to polyvalent and type 14 pneumococcal capsular polysaccharides were measured by a solid-phase antigen-enzyme-labeled anti-Ig immunoassay. One-way analysis of variance showed intrapair total Ig and antibody levels to be more highly correlated in MZ compared with DZ twins. Our results indicate that genetic factors are more important than environment in regulating these humoral immune responses.
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Selected References
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- Allansmith M., McClellan B., Butterworth M. The influence of heredity and environment on human immunoglobulin levels. J Immunol. 1969 Jun;102(6):1504–1510. [PubMed] [Google Scholar]
- Bluestein H. G., Green I., Benacerraf B. Specific immune response genes of the guinea pig. I. Dominant genetic control of immune responsiveness to copolymers of L-glutamic acid and L-alanine and L-glutamic acid and L-tyrosine. J Exp Med. 1971 Aug 1;134(2):458–470. doi: 10.1084/jem.134.2.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carbonara A. O., Ceppellini R., Yount W., Landucci S. The serum Ig level in human twins. Acta Genet Med Gemellol (Roma) 1970 Jan-Apr;19(1):238–238. doi: 10.1017/s1120962300025567. [DOI] [PubMed] [Google Scholar]
- Gray B. M. ELISA methodology for polysaccharide antigens: protein coupling of polysaccharides for adsorption to plastic tubes. J Immunol Methods. 1979;28(1-2):187–192. doi: 10.1016/0022-1759(79)90340-5. [DOI] [PubMed] [Google Scholar]
- Kalff M. W., Hijmans W. Serum immunoglobulin levels in twins. Clin Exp Immunol. 1969 Nov;5(5):469–477. [PMC free article] [PubMed] [Google Scholar]
- Lee S. K., Metrakos J. D., Tanaka K. R., Heiner D. C. Genetic influence on serum igd levels. Pediatr Res. 1980 Jan;14(1):60–63. doi: 10.1203/00006450-198001000-00014. [DOI] [PubMed] [Google Scholar]
- Levine B. B., Stember R. H., Fotino M. Ragweed hay fever: genetic control and linkage to HL-A haplotypes. Science. 1972 Dec 15;178(4066):1201–1203. doi: 10.1126/science.178.4066.1201. [DOI] [PubMed] [Google Scholar]
- Lykken D. T. The diagnosis of zygosity in twins. Behav Genet. 1978 Sep;8(5):437–473. doi: 10.1007/BF01067939. [DOI] [PubMed] [Google Scholar]
- Marsh D. G., Bias W. B., Ishizaka K. Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3588–3592. doi: 10.1073/pnas.71.9.3588. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pandey J. P., Zollinger W. D., Fudenberg H. H., Loadholt C. B. Immunoglobulin allotypes and immune response to meningococcal group B polysaccharide. J Clin Invest. 1981 Nov;68(5):1378–1380. doi: 10.1172/JCI110387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rowe D. S., Boyle J. A., Buchanan W. W. Plasma immunoglobulin concentrations in twins. Clin Exp Immunol. 1968 Mar;3(3):233–244. [PMC free article] [PubMed] [Google Scholar]
- SANG J. H., SOBEY W. R. The genetic control of response to antigenic stimuli. J Immunol. 1954 Jan;72(1):52–65. [PubMed] [Google Scholar]
- Weiss J. B., Austin R. K., Schanfield M. S., Kagnoff M. F. Gluten-sensitive enteropathy. Immunoglobulin G heavy-chain (Gm) allotypes and the immune response to wheat gliadin. J Clin Invest. 1983 Jul;72(1):96–101. doi: 10.1172/JCI110988. [DOI] [PMC free article] [PubMed] [Google Scholar]