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. 1986 Nov;78(5):1199–1205. doi: 10.1172/JCI112703

Dietary protein restriction in established renal injury in the rat. Selective role of glomerular capillary pressure in progressive glomerular dysfunction.

K A Nath, S M Kren, T H Hostetter
PMCID: PMC423805  PMID: 3771792

Abstract

Dietary protein restriction imposed before renal injury is established in the remnant kidney model in the rat reduces glomerular hypertension and hyperperfusion and renal injury. We demonstrate that dietary protein restriction (6% vs. 20%) imposed on a background of established renal injury in the remnant model leads to a greater preservation of renal function as measured by glomerular filtration rate and fractional clearances of albumin and IgG, despite the persistence of systemic hypertension. In similarly prepared rats, dietary protein restriction (6% vs. 20%) led to a lower glomerular capillary hydraulic pressure, a higher ultrafiltration coefficient, and similar single nephron filtration rates. In addition, less impairment of glomerular permselectivity was demonstrable after protein restriction. Our data demonstrate that the preservation of renal function with dietary protein restriction after established glomerular injury follows upon reduction of glomerular capillary hydraulic pressure, despite constancy of single nephron filtration rate and plasma flow and persistence of arterial hypertension.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson S., Meyer T. W., Rennke H. G., Brenner B. M. Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass. J Clin Invest. 1985 Aug;76(2):612–619. doi: 10.1172/JCI112013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baylis C., Rennke H. G. Renal hemodynamics and glomerular morphology in repetitively pregnant aging rats. Kidney Int. 1985 Aug;28(2):140–145. doi: 10.1038/ki.1985.133. [DOI] [PubMed] [Google Scholar]
  3. Bosch J. P., Saccaggi A., Lauer A., Ronco C., Belledonne M., Glabman S. Renal functional reserve in humans. Effect of protein intake on glomerular filtration rate. Am J Med. 1983 Dec;75(6):943–950. doi: 10.1016/0002-9343(83)90873-2. [DOI] [PubMed] [Google Scholar]
  4. Deen W. M., Bohrer M. P., Brenner B. M. Macromolecule transport across glomerular capillaries: application of pore theory. Kidney Int. 1979 Sep;16(3):353–365. doi: 10.1038/ki.1979.138. [DOI] [PubMed] [Google Scholar]
  5. Deen W. M., Robertson C. R., Brenner B. M. A model of glomerular ultrafiltration in the rat. Am J Physiol. 1972 Nov;223(5):1178–1183. doi: 10.1152/ajplegacy.1972.223.5.1178. [DOI] [PubMed] [Google Scholar]
  6. Deen W. M., Troy J. L., Robertson C. R., Brenner B. M. Dynamics of glomerular ultrafiltration in the rat. IV. Determination of the ultrafiltration coefficient. J Clin Invest. 1973 Jun;52(6):1500–1508. doi: 10.1172/JCI107324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dworkin L. D., Hostetter T. H., Rennke H. G., Brenner B. M. Hemodynamic basis for glomerular injury in rats with desoxycorticosterone-salt hypertension. J Clin Invest. 1984 May;73(5):1448–1461. doi: 10.1172/JCI111349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Dworkin L. D., Ichikawa I., Brenner B. M. Hormonal modulation of glomerular function. Am J Physiol. 1983 Feb;244(2):F95–104. doi: 10.1152/ajprenal.1983.244.2.F95. [DOI] [PubMed] [Google Scholar]
  9. Edwards R. M. Segmental effects of norepinephrine and angiotensin II on isolated renal microvessels. Am J Physiol. 1983 May;244(5):F526–F534. doi: 10.1152/ajprenal.1983.244.5.F526. [DOI] [PubMed] [Google Scholar]
  10. El-Nahas A. M., Paraskevakou H., Zoob S., Rees A. J., Evans D. J. Effect of dietary protein restriction on the development of renal failure after subtotal nephrectomy in rats. Clin Sci (Lond) 1983 Oct;65(4):399–406. doi: 10.1042/cs0650399. [DOI] [PubMed] [Google Scholar]
  11. Friedman S., Strober S., Field E. H., Silverman E., Myers B. D. Glomerular capillary wall function in human lupus nephritis. Am J Physiol. 1984 May;246(5 Pt 2):F580–F591. doi: 10.1152/ajprenal.1984.246.5.F580. [DOI] [PubMed] [Google Scholar]
  12. Friend P. S., Fernandes G., Good R. A., Michael A. F., Yunis E. J. Dietary restrictions early and late: effects on the nephropathy of the NZB X NZW mouse. Lab Invest. 1978 Jun;38(6):629–632. [PubMed] [Google Scholar]
  13. Gertz K. H., Mangos J. A., Braun G., Pagel H. D. Pressure in the glomerular capillaries of the rat kidney and its relation to arterial blood pressure. Pflugers Arch Gesamte Physiol Menschen Tiere. 1966;288(4):369–374. doi: 10.1007/BF00362581. [DOI] [PubMed] [Google Scholar]
  14. Hostetter T. H., Olson J. L., Rennke H. G., Venkatachalam M. A., Brenner B. M. Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. Am J Physiol. 1981 Jul;241(1):F85–F93. doi: 10.1152/ajprenal.1981.241.1.F85. [DOI] [PubMed] [Google Scholar]
  15. Hostetter T. H., Rennke H. G., Brenner B. M. The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies. Am J Med. 1982 Mar;72(3):375–380. doi: 10.1016/0002-9343(82)90490-9. [DOI] [PubMed] [Google Scholar]
  16. Ichikawa I., Purkerson M. L., Klahr S., Troy J. L., Martinez-Maldonado M., Brenner B. M. Mechanism of reduced glomerular filtration rate in chronic malnutrition. J Clin Invest. 1980 May;65(5):982–988. doi: 10.1172/JCI109784. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Klahr S., Buerkert J., Purkerson M. L. Role of dietary factors in the progression of chronic renal disease. Kidney Int. 1983 Nov;24(5):579–587. doi: 10.1038/ki.1983.197. [DOI] [PubMed] [Google Scholar]
  18. Kleinknecht C., Salusky I., Broyer M., Gubler M. C. Effect of various protein diets on growth, renal function, and survival of uremic rats. Kidney Int. 1979 May;15(5):534–541. doi: 10.1038/ki.1979.68. [DOI] [PubMed] [Google Scholar]
  19. Mitch W. E. The influence of the diet on the progression of renal insufficiency. Annu Rev Med. 1984;35:249–264. doi: 10.1146/annurev.me.35.020184.001341. [DOI] [PubMed] [Google Scholar]
  20. Myers B. D., Okarma T. B., Friedman S., Bridges C., Ross J., Asseff S., Deen W. M. Mechanisms of proteinuria in human glomerulonephritis. J Clin Invest. 1982 Oct;70(4):732–746. doi: 10.1172/JCI110669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Neugarten J., Feiner H. D., Schacht R. G., Baldwin D. S. Amelioration of experimental glomerulonephritis by dietary protein restriction. Kidney Int. 1983 Nov;24(5):595–601. doi: 10.1038/ki.1983.199. [DOI] [PubMed] [Google Scholar]
  22. Olson J. L., Hostetter T. H., Rennke H. G., Brenner B. M., Venkatachalam M. A. Altered glomerular permselectivity and progressive sclerosis following extreme ablation of renal mass. Kidney Int. 1982 Aug;22(2):112–126. doi: 10.1038/ki.1982.143. [DOI] [PubMed] [Google Scholar]
  23. Purkerson M. L., Hoffsten P. E., Klahr S. Pathogenesis of the glomerulopathy associated with renal infarction in rats. Kidney Int. 1976 May;9(5):407–417. doi: 10.1038/ki.1976.50. [DOI] [PubMed] [Google Scholar]
  24. Purkerson M. L., Joist J. H., Yates J., Valdes A., Morrison A., Klahr S. Inhibition of thromboxane synthesis ameliorates the progressive kidney disease of rats with subtotal renal ablation. Proc Natl Acad Sci U S A. 1985 Jan;82(1):193–197. doi: 10.1073/pnas.82.1.193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Rodríguez-Iturbe B., Herrera J., García R. Response to acute protein load in kidney donors and in apparently normal postacute glomerulonephritis patients: evidence for glomerular hyperfiltration. Lancet. 1985 Aug 31;2(8453):461–464. doi: 10.1016/s0140-6736(85)90399-x. [DOI] [PubMed] [Google Scholar]
  26. Rosman J. B., ter Wee P. M., Meijer S., Piers-Becht T. P., Sluiter W. J., Donker A. J. Prospective randomised trial of early dietary protein restriction in chronic renal failure. Lancet. 1984 Dec 8;2(8415):1291–1296. doi: 10.1016/s0140-6736(84)90818-3. [DOI] [PubMed] [Google Scholar]
  27. Schoolwerth A. C., Sandler R. S., Hoffman P. M., Klahr S. Effects of nephron reduction and dietary protein content on renal ammoniagenesis in the rat. Kidney Int. 1975 Jun;7(6):397–404. doi: 10.1038/ki.1975.57. [DOI] [PubMed] [Google Scholar]
  28. Schor N., Ichikawa I., Brenner B. M. Mechanisms of action of various hormones and vasoactive substances on glomerular ultrafiltration in the rat. Kidney Int. 1981 Oct;20(4):442–451. doi: 10.1038/ki.1981.160. [DOI] [PubMed] [Google Scholar]
  29. Viberti G. C., Mackintosh D., Bilous R. W., Pickup J. C., Keen H. Proteinuria in diabetes mellitus: role of spontaneous and experimental variation of glycemia. Kidney Int. 1982 May;21(5):714–720. doi: 10.1038/ki.1982.87. [DOI] [PubMed] [Google Scholar]

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