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. 1985 Oct;76(4):1695–1698. doi: 10.1172/JCI112157

Erythrocyte survival in chronic renal failure. Role of secondary hyperparathyroidism.

M Akmal, N Telfer, A N Ansari, S G Massry
PMCID: PMC424168  PMID: 4056047

Abstract

The human erythrocyte (RBC) is a target organ for parathyroid hormone (PTH) and the hormone increases RBC osmotic fragility and induces their hemolysis. The present study was undertaken to examine whether elevated blood levels of PTH affect RBC survival, and therefore whether PTH, being an extracorpuscular factor, is responsible for the shortened RBC survival in chronic renal failure. 51Cr-labeled RBC survival was elevated in six normal dogs, in six animals with chronic renal failure and secondary hyperparathyroidism (NPX), and in six thyroparathyroidectomized dogs (NPX-TPTX) with comparable degree and duration of chronic renal failure. In the normal dogs, 51Cr-labeled RBC survival ranged between 22 and 35 (25.6 +/- 1.9) d. In the NPX dogs, 51Cr-labeled RBC survival was shortened and the values ranged between 16 and 20 (18.4 +/- 0.6) d, a value significantly (P less than 0.01) lower than normal dogs. In NPX-TPTX dogs, 51Cr-labeled RBC survival ranged between 20 and 33 (25.2 +/- 1.8) d, a value not different from that in normal dogs but significantly higher (P less than 0.01) than that in NPX animals. Our data demonstrate that excess blood levels of PTH and not other consequences of the uremic state are responsible for the shortened RBC survival in chronic renal failure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnaud C. D. Hyperparathyroidism and renal failure. Kidney Int. 1973 Aug;4(2):89–95. doi: 10.1038/ki.1973.87. [DOI] [PubMed] [Google Scholar]
  2. Blumberg A., Marti H. R. Red cell metabolism and haemolysis in patients on dialysis. Proc Eur Dial Transplant Assoc. 1972;9:91–96. [PubMed] [Google Scholar]
  3. Bogin E., Massry S. G., Levi J., Djaldeti M., Bristol G., Smith J. Effect of parathyroid hormone on osmotic fragility of human erythrocytes. J Clin Invest. 1982 Apr;69(4):1017–1025. doi: 10.1172/JCI110505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DESFORGES J. F., DAWSON J. P. The anemia of renal failure. AMA Arch Intern Med. 1958 Feb;101(2):326–332. doi: 10.1001/archinte.1958.00260140158024. [DOI] [PubMed] [Google Scholar]
  5. Eschbach J. W., Jr, Funk D., Adamson J., Kuhn I., Scribner B. H., Finch C. A. Erythropoiesis in patients with renal failure undergoing chronic dialysis. N Engl J Med. 1967 Mar 23;276(12):653–658. doi: 10.1056/NEJM196703232761202. [DOI] [PubMed] [Google Scholar]
  6. Hefti J. E., Blumberg A., Marti H. R. Red cell survival and red cell enzymes in patients on continuous peritoneal dialysis (CAPD). Clin Nephrol. 1983 May;19(5):232–235. [PubMed] [Google Scholar]
  7. Hocken A. G. Haemolysis in chronic renal failure. Nephron. 1982;32(1):28–31. doi: 10.1159/000182727. [DOI] [PubMed] [Google Scholar]
  8. JOSKE R. A., MCALISTER J. M., PRANKERD T. A. Isotope investigations of red cell production and destruction in chronic renal disease. Clin Sci. 1956 Nov;15(4):511–522. [PubMed] [Google Scholar]
  9. Katz A. I., Hampers C. L., Merrill J. P. Secondary hyperparathyroidism and renal osteodystrophy in chronic renal failure. Analysis of 195 patients, with observations on the effects of chronic dialysis, kidney transplantation and subtotal parathyroidectomy. Medicine (Baltimore) 1969 Sep;48(5):333–374. [PubMed] [Google Scholar]
  10. Massry S. G., Coburn J. W., Peacock M., Kleeman C. R. Turnover of endogenous parathyroid hormone in uremic patients and those undergoing hemodialysis. Trans Am Soc Artif Intern Organs. 1972;18(0):416–422. doi: 10.1097/00002480-197201000-00103. [DOI] [PubMed] [Google Scholar]
  11. Massry S. G. Parathyroid hormone and the uremic manifestations. Contrib Nephrol. 1980;20:84–91. doi: 10.1159/000384957. [DOI] [PubMed] [Google Scholar]
  12. Müller-Wiefel D. E., Sinn H., Gilli G., Schärer K. Hemolysis and blood loss in children with chronic renal failure. Clin Nephrol. 1977 Nov;8(5):481–486. [PubMed] [Google Scholar]
  13. Rath R. N., Das R. K., 4th, Panda R. K., Mahakur A. C., Patnaik S. R. Red cell survival time in chronic renal failure. J Assoc Physicians India. 1979 Oct;27(10):969–974. [PubMed] [Google Scholar]
  14. Saltissi D., Carter G. D. Association of secondary hyperparathyroidism with red cell survival in chronic haemodialysis patients. Clin Sci (Lond) 1985 Jan;68(1):29–33. doi: 10.1042/cs0680029. [DOI] [PubMed] [Google Scholar]
  15. Shaw A. B. Haemolysis in chronic renal failure. Br Med J. 1967 Apr 22;2(5546):213–216. doi: 10.1136/bmj.2.5546.213. [DOI] [PMC free article] [PubMed] [Google Scholar]

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