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. 1984 Jul;74(1):287–291. doi: 10.1172/JCI111413

Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropositive juvenile rheumatoid arthritis.

B S Nepom, G T Nepom, E Mickelson, J G Schaller, P Antonelli, J A Hansen
PMCID: PMC425211  PMID: 6610692

Abstract

The structural and functional heterogeneity of HLA-DR4-associated specificities was investigated in patients with seropositive juvenile rheumatoid arthritis, a DR4-associated disease. Using a combination of HLA-D analysis by mixed lymphocyte culture and electrophoretic analysis of immunoprecipitated Ia molecules by two-dimensional polyacrylamide gels, we observed a surprisingly homogeneous pattern of HLA-D antigen expression. All patients expressed common structural products of the DR and DS loci, and 7/12 homozygous DR4 patients expressed a rare and subtle HLA-D heterozygous phenotype.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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