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. 1972 Mar;69(3):737–741. doi: 10.1073/pnas.69.3.737

Replication of Mitochondrial DNA. Circular Replicative Intermediates in Mouse L Cells

Donald L Robberson 1,2,*, Harumi Kasamatsu 1,2, Jerome Vinograd 1,2,
PMCID: PMC426547  PMID: 4501588

Abstract

The frequency, composition, and structure of circular replicating forms of mitochondrial DNA, including two new forms described here, suggest a scheme for the mode of replication of this DNA.

Keywords: electron microscopy, separated strands, duplex synthesis, displacement synthesis

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnberg A., van Bruggen E. F., Borst P. The presence of DNA molecules with a displacement loop in standard mitochondrial DNA preparations. Biochim Biophys Acta. 1971 Aug 26;246(2):353–357. doi: 10.1016/0005-2787(71)90147-x. [DOI] [PubMed] [Google Scholar]
  2. Bosmann H. B. Mitochondrial biochemical events in a synchronized mammalian cell population. J Biol Chem. 1971 Jun 25;246(12):3817–3823. [PubMed] [Google Scholar]
  3. Bourgaux P., Bourgaux-Ramoisy D., Seiler P. The replication of the ring-shaped DNA of polyoma virus. II. Identification of molecules at various stages of replication. J Mol Biol. 1971 Jul 14;59(1):195–206. doi: 10.1016/0022-2836(71)90421-9. [DOI] [PubMed] [Google Scholar]
  4. Huberman J. A., Riggs A. D. On the mechanism of DNA replication in mammalian chromosomes. J Mol Biol. 1968 Mar 14;32(2):327–341. doi: 10.1016/0022-2836(68)90013-2. [DOI] [PubMed] [Google Scholar]
  5. Jaenisch R., Mayer A., Levine A. Replicating SV40 molecules containing closed circular template DNA strands. Nat New Biol. 1971 Sep 15;233(37):72–75. doi: 10.1038/newbio233072a0. [DOI] [PubMed] [Google Scholar]
  6. Kasamatsu H., Robberson D. L., Vinograd J. A novel closed-circular mitochondrial DNA with properties of a replicating intermediate. Proc Natl Acad Sci U S A. 1971 Sep;68(9):2252–2257. doi: 10.1073/pnas.68.9.2252. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kirschner R. H., Wolstenholme D. R., Gross N. J. Replicating molecules of circular mitochondrial DNA. Proc Natl Acad Sci U S A. 1968 Aug;60(4):1466–1472. doi: 10.1073/pnas.60.4.1466. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lee C. S., Davis R. W., Davidson N. A physical study by electron microscopy of the terminally reptitious, circularly permuted DNA from the coliphage particles of Escherichia coli 15. J Mol Biol. 1970 Feb 28;48(1):1–22. doi: 10.1016/0022-2836(70)90215-9. [DOI] [PubMed] [Google Scholar]
  9. Meinke W., Goldstein D. A. Studies on the structure and formation of polyoma DNA replicative intermediates. J Mol Biol. 1971 Nov 14;61(3):543–563. doi: 10.1016/0022-2836(71)90064-7. [DOI] [PubMed] [Google Scholar]
  10. Pica-Mattoccia L., Attardi G. Expression of the mitochondrial genome in HeLa cells. V. Transcription of mitochondrial DNA in relationship to the cell cycle. J Mol Biol. 1971 May 14;57(3):615–621. doi: 10.1016/0022-2836(71)90113-6. [DOI] [PubMed] [Google Scholar]
  11. Sebring E. D., Kelly T. J., Jr, Thoren M. M., Salzman N. P. Structure of replicating simian virus 40 deoxyribonucleic acid molecules. J Virol. 1971 Oct;8(4):478–490. doi: 10.1128/jvi.8.4.478-490.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]

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