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. 1972 Apr;69(4):809–811. doi: 10.1073/pnas.69.4.809

Nonprotein Amino Acids from Spark Discharges and Their Comparison with the Murchison Meteorite Amino Acids

Yecheskel Wolman 1,*, William J Haverland 1, Stanley L Miller 1,†
PMCID: PMC426569  PMID: 16591973

Abstract

All the nonprotein amino acids found in the Murchison meteorite are products of the action of electric discharge on a mixture of methane, nitrogen, and water with traces of ammonia. These amino acids include α-amino-n-butyric acid, α-aminoisobutyric acid, norvaline, isovaline, pipecolic acid, β-alanine, β-amino-n-butyric acid, β-aminoisobutyric acid, γ-aminobutyric acid, sarcosine, N-ethylglycine, and N-methylalanine. In addition, norleucine, alloisoleucine, N-propylglycine, N-isopropylglycine, N-methyl-β-alanine, N-ethyl-β-alanine α,β-diaminopropionic acid, isoserine, α,γ-diaminobutyric acid, and α-hydroxy-γ-aminobutyric acid are produced by the electric discharge, but have not been found in the meteorite.

Keywords: gas chromatography-mass spectrometry, prebiotic synthesis, amino-acid analyzer

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Coggins J. R., Benoiton N. L. Determination of N-methylamino acids and their optical purity with an amino acid analyzer. J Chromatogr. 1970 Oct 21;52(2):251–256. doi: 10.1016/s0021-9673(01)96572-0. [DOI] [PubMed] [Google Scholar]
  2. Cronin J. R., Moore C. B. Amino Acid analyses of the murchison, murray, and allende carbonaceous chondrites. Science. 1971 Jun 25;172(3990):1327–1329. doi: 10.1126/science.172.3990.1327. [DOI] [PubMed] [Google Scholar]
  3. Kvenvolden K. A., Lawless J. G., Ponnamperuma C. Nonprotein amino acids in the murchison meteorite. Proc Natl Acad Sci U S A. 1971 Feb;68(2):486–490. doi: 10.1073/pnas.68.2.486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kvenvolden K., Lawless J., Pering K., Peterson E., Flores J., Ponnamperuma C., Kaplan I. R., Moore C. Evidence for extraterrestrial amino-acids and hydrocarbons in the Murchison meteorite. Nature. 1970 Dec 5;228(5275):923–926. doi: 10.1038/228923a0. [DOI] [PubMed] [Google Scholar]
  5. MILLER S. L. A production of amino acids under possible primitive earth conditions. Science. 1953 May 15;117(3046):528–529. doi: 10.1126/science.117.3046.528. [DOI] [PubMed] [Google Scholar]
  6. MILLER S. L. The mechanism of synthesis of amino acids by electric discharges. Biochim Biophys Acta. 1957 Mar;23(3):480–489. doi: 10.1016/0006-3002(57)90366-9. [DOI] [PubMed] [Google Scholar]
  7. Oró J., Gibert J., Lichtenstein H., Wikstrom S., Flory D. A. Amino-acids, aliphatic and aromatic hydrocarbons in the Murchison Meteorite. Nature. 1971 Mar 12;230(5289):105–106. doi: 10.1038/230105a0. [DOI] [PubMed] [Google Scholar]
  8. Ponnamperuma C., Woeller F. Alpha-aminonitriles formed by an electric discharge through a mixture of anhydrous methane and ammonia. Curr Mod Biol. 1967 May;1(2):156–158. doi: 10.1016/0303-2647(67)90031-7. [DOI] [PubMed] [Google Scholar]
  9. Ring D., Wolman Y., Friedmann N., Miller S. L. Prebiotic synthesis of hydrophobic and protein amino acids. Proc Natl Acad Sci U S A. 1972 Mar;69(3):765–768. doi: 10.1073/pnas.69.3.765. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sanchez R. A., Ferris J. P., Orgel L. E. Cyanoacetylene in prebiotic synthesis. Science. 1966 Nov 11;154(3750):784–785. doi: 10.1126/science.154.3750.784. [DOI] [PubMed] [Google Scholar]
  11. Urey H. C. On the Early Chemical History of the Earth and the Origin of Life. Proc Natl Acad Sci U S A. 1952 Apr;38(4):351–363. doi: 10.1073/pnas.38.4.351. [DOI] [PMC free article] [PubMed] [Google Scholar]

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