Abstract
Whole mycobacterial cells, which are used in Freund's complete adjuvant, besides inducing hypersensitivity to tuberculoprotein, also can elicit hyperreactivity to endotoxins, lymphoid hyperplasia, and allergic polyarthritis in rats. The data reported here demonstrate that a potent water-soluble adjuvant obtained from mycobacterial cell walls is also effective in increasing the immune response to viruses, and that it is free of the toxic effects observed with whole mycobacterial cells.
Keywords: glycopeptide, agglutinins, precipitins, nonspecific immunity
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adam A., Ciorbaru R., Petit J. F., Lederer E. Isolation and properties of a macromolecular, water-soluble, immuno-adjuvant fraction from the cell wall of Mycobacterium smegmatis. Proc Natl Acad Sci U S A. 1972 Apr;69(4):851–854. doi: 10.1073/pnas.69.4.851. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bekierkunst A., Levij I. S., Yarkoni E., Vilkas E., Adam A., Lederer E. Granuloma formation induced in mice by chemically defined mycobacterial fractions. J Bacteriol. 1969 Oct;100(1):95–102. doi: 10.1128/jb.100.1.95-102.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Berman L. D., Allison A. C., Pereira H. G. Effects of Freund's adjuvant on adenovirus oncogenesis and antibody production in hamsters. Int J Cancer. 1967 Sep 15;2(5):539–543. doi: 10.1002/ijc.2910020515. [DOI] [PubMed] [Google Scholar]
- Davenport F. M. Seventeen years' experience with mineral oil adjuvant influenza virus vaccines. Ann Allergy. 1968 Jun;26(6):288–292. [PubMed] [Google Scholar]
- HALPERN B. N., BIOZZI G., HOWARD J., STIFFEL C., MOUTON D. Exaltation du pouvoir toxique d'Eberthella typhosa tuée chez la souris inoculée avec le B. C. G. vivant; relation entre cette augmentation de la susceptibilité et l'état fonctionnel du système réticulo-endothélial. C R Seances Soc Biol Fil. 1958;152(6):899–902. [PubMed] [Google Scholar]
- Hirst G. K. THE AGGLUTINATION OF RED CELLS BY ALLANTOIC FLUID OF CHICK EMBRYOS INFECTED WITH INFLUENZA VIRUS. Science. 1941 Jul 4;94(2427):22–23. doi: 10.1126/science.94.2427.22. [DOI] [PubMed] [Google Scholar]
- NEVEU T., BRANELLEC A., BIOZZI G. PROPRI'ET'ES ADJUVANTES DE CORYNEBACTERIUM PARVUM SUR LA PRODUCTION D'ANTICORPS ET SUR L'INDUCTION DE L'HYPERSENSIBILIT'E RETARD'EE ENVERS LES PROT'EINES CONJUGU'EES. Ann Inst Pasteur (Paris) 1964 May;106:771–777. [PubMed] [Google Scholar]
- SUTER E., ULLMAN G. E., HOFFMAN R. G. Sensitivity of mice to endotoxin after vaccination with BCG (Bacillus Calmette-Guérin). Proc Soc Exp Biol Med. 1958 Oct;99(1):167–169. doi: 10.3181/00379727-99-24282. [DOI] [PubMed] [Google Scholar]
- Stiffel C., Mouton D., Biozzi G. Rôle des macrophages dans l'immunité non spécifique. Ann Inst Pasteur (Paris) 1971 Mar;120(3):412–427. [PubMed] [Google Scholar]
- WAKSMAN B. H., PEARSON C. M., SHARP J. T. Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen. J Immunol. 1960 Oct;85:403–417. [PubMed] [Google Scholar]
- Zbar B., Bernstein I., Tanaka T., Rapp H. J. Tumor immunity produced by the intradermal inoculation of living tumor cells and living Mycobacterium bovis (strain BCG). Science. 1970 Dec 11;170(3963):1217–1218. doi: 10.1126/science.170.3963.1217. [DOI] [PubMed] [Google Scholar]
- Zbar B., Tanaka T. Immunotherapy of cancer: regression of tumors after intralesional injection of living Mycobacterium bovis. Science. 1971 Apr 16;172(3980):271–273. doi: 10.1126/science.172.3980.271. [DOI] [PubMed] [Google Scholar]