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. 1972 Jun;69(6):1592–1595. doi: 10.1073/pnas.69.6.1592

Juvenile Hormone Induction of Esterases: A Mechanism for the Regulation of Juvenile Hormone Titer

Donald Whitmore Jr 1, Elaine Whitmore 1, Lawrence I Gilbert 1
PMCID: PMC426755  PMID: 4504374

Abstract

Within a few hours after injection of juvenile hormone into Hyalophora gloveri pupae, several fast-migrating carboxylesterases (EC 3.1.1.1) that are sensitive to diisopropylfluorophosphate appear in the hemolymph. Treatment of the pupae with puromycin or actinomycin D prevents the appearance of these hemolymph enzymes, suggesting de novo synthesis of the carboxylesterases. Of the several other compounds investigated, only a potent mimic of the juvenile hormone is able to induce these enzymes. When the induced enzymes are incubated in vitro with 14C-labeled juvenile hormone, the hormone is rapidly and efficiently degraded. It is suggested that these induced carboxylesterases play an important role in the regulation of juvenile hormone titer.

Keywords: Hyalophora gloveri, pupa, hemolymph

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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