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. 1972 Jul;69(7):1758–1760. doi: 10.1073/pnas.69.7.1758

Diphenylhydantoin Inhibition of Sodium Conductance in Squid Giant Axon

Raymond J Lipicky *, Daniel L Gilbert †, Irving M Stillman †
PMCID: PMC426796  PMID: 4505652

Abstract

Diphenylhydantoin, in concentration of 5-50 μM, decreases the early, transient (sodium) currents of voltage-clamped squid giant axons. These effects are dose-dependent and largely reversible. It appears that diphenylhydantoin reduces the number of open, early, transient (sodium) channels.

Keywords: dilantin, antiarrhythmic, voltage clamp, anticonvulsant, potassium conductance

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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