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. 1972 Aug;69(8):2061–2065. doi: 10.1073/pnas.69.8.2061

The Stabilization of Episomal Integration by Genetic Inversion: A General Hypothesis

Edward A Adelberg *, Peter Bergquist †
PMCID: PMC426868  PMID: 4559592

Abstract

In F′ cells of Escherichia coli K12, recombination in the region of genetic duplication between chromosome and F-genote produces a rapid alteration between the integrated and detached states of the episome. Nevertheless, F′ strains can give rise to Hfr cells in which the F-genote has undergone stable integration. We have found that one such Hfr has retained the genetic duplication as well as the recombination proficiency of the parental F′ strain; to account for the failure of recombination to detach the episome in this Hfr, we have postulated the inversion of one of the duplicated regions. A general model is presented, showing that an inversion must prevent episome detachment by any combination of genetic crossovers.

Keywords: E. coli, recombination, crossover

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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