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. 1972 Aug;69(8):2203–2207. doi: 10.1073/pnas.69.8.2203

Negative Control of Protein Synthesis after Infection with Bacteriophage T7

Manfred Schweiger 1, Peter Herrlich 1, Eberhard Scherzinger 1, Hans J Rahmsdorf 1
PMCID: PMC426900  PMID: 4559598

Abstract

T7 phage induces two negative control mechanisms of protein synthesis: (a) Host-gene expression is repressed by a “T7 repressor,” and (b) early T7 protein synthesis is inhibited by a late phage protein.

(a) The repressor for host enzyme synthesis is an early T7 protein. Its gene is none of the known early genes; it is located promotor-proximal to gene 1. The repressor function of this protein can be demonstrated by DNA-dependent enzyme synthesis in vitro.

(b) Expression of early phage gene is depressed by a late phage protein or by T7 RNA polymerase. Control takes place on the level of transcription.

Keywords: E. coli, S-adenosyl methionine cleavage, T3 phage, RNA polymerase

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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