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. 1972 Aug;69(8):2212–2215. doi: 10.1073/pnas.69.8.2212

Stereochemistry of a Curare Alkaloid: O,O′,N-Trimethyl-d-Tubocurarine

Henry M Sobell *,*,†, T D Sakore *,*,†, S S Tavale *,*,†,§, F G Canepa *,*,†,†,, Peter Pauling *,*,†,†, Trevor J Petcher *,*,†,†
PMCID: PMC426902  PMID: 4506090

Abstract

The three-dimensional structure of O,O′,N-trimethyl-d-tubocurarine, a neuromuscular blocking agent, has been determined by x-ray crystallography. This may help to provide insight into its pharmacologic action.

Keywords: x-ray crystallography, neuromuscular blocking agent

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beers W. H., Reich E. Structure and activity of acetylcholine. Nature. 1970 Dec 5;228(5275):917–922. doi: 10.1038/228917a0. [DOI] [PubMed] [Google Scholar]
  2. CHANG C. C., LEE C. Y. ISOLATION OF NEUROTOXINS FROM THE VENOM OF BUNGARUS MULTICINCTUS AND THEIR MODES OF NEUROMUSCULAR BLOCKING ACTION. Arch Int Pharmacodyn Ther. 1963 Jul 1;144:241–257. [PubMed] [Google Scholar]
  3. Changeux J. P., Kasai M., Lee C. Y. Use of a snake venom toxin to characterize the cholinergic receptor protein. Proc Natl Acad Sci U S A. 1970 Nov;67(3):1241–1247. doi: 10.1073/pnas.67.3.1241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DEL CASTILLO L., KATZ B. A study of curare action with an electrical micromethod. Proc R Soc Lond B Biol Sci. 1957 May 7;146(924):339–356. doi: 10.1098/rspb.1957.0015. [DOI] [PubMed] [Google Scholar]
  5. Lee C. Y., Tseng L. F., Chiu T. H. Influence of denervation on localization of neurotoxins from clapid venoms in rat diaphragm. Nature. 1967 Sep 9;215(5106):1177–1178. doi: 10.1038/2151177a0. [DOI] [PubMed] [Google Scholar]
  6. Miledi R., Molinoff P., Potter L. T. Isolation of the cholinergic receptor protein of Torpedo electric tissue. Nature. 1971 Feb 19;229(5286):554–557. doi: 10.1038/229554a0. [DOI] [PubMed] [Google Scholar]
  7. Miledi R., Potter L. T. Acetylcholine receptors in muscle fibres. Nature. 1971 Oct 29;233(5322):599–603. doi: 10.1038/233599a0. [DOI] [PubMed] [Google Scholar]
  8. Sobell H. M., Jain S. C., Sakore T. D., Nordman C. E. Stereochemistry of actinomycin--DNA binding. Nat New Biol. 1971 Jun 16;231(24):200–205. doi: 10.1038/newbio231200a0. [DOI] [PubMed] [Google Scholar]

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