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. 1973 Oct;70(10):2993–2996. doi: 10.1073/pnas.70.10.2993

Collagen Synthesis: A Disulfide-Linked Collagen Precursor in Chick Bone*

L I Fessler 1, R E Burgeson 1, N P Morris 1, J H Fessler 1
PMCID: PMC427154  PMID: 4517950

Abstract

Chick calvaria labeled in vitro contain a triple-stranded collagen precursor that contains two pro α1 and one pro α2 chains. All chains contain cystine and are linked by S-S bonds. Ultracentrifugal analysis was used to measure the relative size of the disulfide-linked units. It is proposed that the S-S links help to determine the correct alignment of the triple-stranded structure.

Keywords: calvaria, ultracentrifugation

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Selected References

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