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. 1973 Dec;70(12 Pt 1-2):3759–3763. doi: 10.1073/pnas.70.12.3759

Sodium Uptake Associated with Activation of Action Potential Ionophores of Cultured Neuroblastoma and Muscle Cells

William A Catterall 1, Marshall Nirenberg 1
PMCID: PMC427322  PMID: 4521201

Abstract

Veratridine, an activator of action potential Na+ ionophores, stimulated passive Na+ uptake by electrically excitable neuroblastoma and muscle cells but had no effect on clonal cell lines defective in Na+-ionophore activity. Veratridine-dependent Na+ uptake was completely inhibited by tetrodotoxin, a specific inhibitor of the action potential Na+ ionophore. Half-maximal inhibition was obtained with 11 nM tetrodotoxin. Thus, veratridinedependent Na+ uptake provides a specific and convenient means of assaying populations of cultured cells for action potential Na+-ionophore activity.

Keywords: excitable membranes, hybrid cells, veratridine, tetrodotoxin

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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