Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1974 Jan;5(1):25–32. doi: 10.1128/aac.5.1.25

Cefoxitin, a Semisynthetic Cephamycin Antibiotic: Susceptibility Studies

Hyman Wallick 1, David Hendlin 1
PMCID: PMC428914  PMID: 4840447

Abstract

Cefoxitin, 3-carbamoyloxymethyl-7-α-methoxy-7-[2-(2-thienyl)acetamido]-3-cephem-4- carboxylic acid, is a new semisynthetic cephamycin with broad antibacterial activity. It is highly active against gram-negative microorganisms including indole-positive Proteus and Serratia strains, which are ordinarily reistant to the cephalosporins. Cefoxitin is also highly active against many strains of Escherichia coli and Proteus mirabilis which are resistant to the cephalosporins. Furthermore, E. coli and Klebsiella strains which are susceptible to the cephalosporins are generally more susceptible to the cephamycin analog. The susceptibility of the gram-positive bacteria falls well within the effective range of the antibiotic for gram-negative organisms, but cefoxitin is less active than cephalothin or cephaloridine. As is the case with the cephalosporins, strains of Pseudomonas and group D streptococci are resistant to cefoxitin. Changes in pH, inoculum density, and growth medium have no significant effect on the activity of the antibiotic.

Full text

PDF
26

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
  2. Cama L. D., Leanza W. J., Beattie T. R., Christensen B. G. Substituted penicillin and cephalosporin derivatives. I. Stereospecific introduction of the C-6(7) methoxy group. J Am Chem Soc. 1972 Feb 23;94(4):1408–1410. doi: 10.1021/ja00759a089. [DOI] [PubMed] [Google Scholar]
  3. GRIFFITH R. S., BLACK H. R. CEPHALOTHIN--A NEW ANTIBIOTIC. PRELIMINARY CLINICAL AND LABORATORY STUDIES. JAMA. 1964 Sep 14;189:823–828. [PubMed] [Google Scholar]
  4. Miller A. K., Celozzi E., Kong Y., Pelak B. A., Hendlin D., Stapley E. O. Cefoxitin, a semisynthetic cephamycin antibiotic: in vivo evaluation. Antimicrob Agents Chemother. 1974 Jan;5(1):33–37. doi: 10.1128/aac.5.1.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Miller A. K., Celozzi E., Kong Y., Pelak B. A., Kropp H., Stapley E. O., Hendlin D. Cephamycins, a new family of beta-lactam antibiotics. IV. In vivo studies. Antimicrob Agents Chemother. 1972 Oct;2(4):287–290. doi: 10.1128/aac.2.4.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Miller A. K., Celozzi E., Pelak B. A., Stapley E. O., Hendlin D. Cephamycins, a new family of beta-lactam antibiotics. 3. In vitro studies. Antimicrob Agents Chemother. 1972 Oct;2(4):281–286. doi: 10.1128/aac.2.4.281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Miller T. W., Goegelman R. T., Weston R. G., Putter I., Wolf F. J. Cephamycins, a new family of beta-lactam antibiotics. II. Isolation and chemical characterization. Antimicrob Agents Chemother. 1972 Sep;2(3):132–135. doi: 10.1128/aac.2.3.132. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Nagarajan R., Boeck L. D., Gorman M., Hamill R. L., Higgens C. E., Hoehn M. M., Stark W. M., Whitney J. G. Beta-lactam antibiotics from Streptomyces. J Am Chem Soc. 1971 May 5;93(9):2308–2310. doi: 10.1021/ja00738a035. [DOI] [PubMed] [Google Scholar]
  9. Stapley E. O., Jackson M., Hernandez S., Zimmerman S. B., Currie S. A., Mochales S., Mata J. M., Woodruff H. B., Hendlin D. Cephamycins, a new family of beta-lactam antibiotics. I. Production by actinomycetes, including Streptomyces lactamdurans sp. n. Antimicrob Agents Chemother. 1972 Sep;2(3):122–131. doi: 10.1128/aac.2.3.122. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Steigbigel N. H., McCall C. E., Reed C. W., Finland M. Antibacterial action of "broad-spectrum" penicillins, cephalosporins and other antibiotics against Gram-negative bacilli isolated from bacteremic patients. Ann N Y Acad Sci. 1967 Sep 27;145(2):224–236. doi: 10.1111/j.1749-6632.1967.tb50221.x. [DOI] [PubMed] [Google Scholar]
  11. Wick W. E. In vitro and in vivo laboratory comparison of cephalothin and desacetylcephalothin. Antimicrob Agents Chemother (Bethesda) 1965;5:870–875. [PubMed] [Google Scholar]
  12. Wick W. E., Preston D. A. Biological properties of three 3-heterocyclic-thiomethyl cephalosporin antibiotics. Antimicrob Agents Chemother. 1972 Mar;1(3):221–234. doi: 10.1128/aac.1.3.221. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES