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. 1974 Apr;5(4):398–402. doi: 10.1128/aac.5.4.398

Inactivation of Herpes Simplex Virus by Thiosemicarbazones and Certain Cations

Warren Levinson 1,2, Virginia Coleman 1,2, Bruce Woodson 1,2, Alan Rabson 1,2, Jeff Lanier 1,2, Jack Whitcher 1,2, Chandler Dawson 1,2
PMCID: PMC428982  PMID: 15825395

Abstract

We demonstrated that herpes simplex virus types 1 and 2, including a type 2 strain which transforms hamster cells in vitro, and Herpesvirus saimiri are inactivated by exposure to thiosemicarbazones. Because thiosemicarbazones are thought to interact with heavy metals in this inactivation process (9), we tested and found some of these herpesviruses to be susceptible to exposure to certain heavy metals. A virion polymerase was sought because the ribonucleic acid (RNA)-dependent deoxyribonucleic acid (DNA) polymerase of Rous sarcoma virus and the DNA-dependent RNA polymerase of vaccinia virus are inhibited. However, neither DNA nor RNA polymerase activity could be demonstrated in herpes simplex virions. The ability of thiosemicarbazone to ameliorate the course of herpes simplex virus infection in rabbit eyes was observed, but was considered insufficient to be of clinical importance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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