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. 1974 May;5(5):473–478. doi: 10.1128/aac.5.5.473

Combined Amphotericin B-Tetracycline Therapy for Experimental Coccidioidomycosis

M Huppert 1, Sung H Sun 1, Katherine R Vukovich 1
PMCID: PMC428998  PMID: 4462463

Abstract

Although amphotericin B is the principal antibiotic for treating systemic mycoses, its clinical use is restricted, primarily because of the toxicity associated with the required prolonged therapy. Other investigators have reported results from in vitro experiments demonstrating that amphotericin B can potentiate antifungal activity of other antibiotics which are ineffective when used alone. In the present study, amphotericin B was used in combination with tetracycline for treating experimental coccidioidomycosis in mice. The results show that the combination of antibiotics is effective with a dosage of amphotericin B reduced 2.5 to 4 times of that required for effective chemotherapy with amphotericin B alone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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