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. 1974 Jun;5(6):553–557. doi: 10.1128/aac.5.6.553

Inactivation of Dihydrostreptomycin and Spectinomycin by Staphylococcus aureus

Haruhide Kawabe 1, Matsuhisa Inoue 1, Susumu Mitsuhashi 1
PMCID: PMC429012  PMID: 15825403

Abstract

Three types of Staphylococcus aureus strains were isolated with respect to streptomycin (SM) and spectinomycin (SPC) resistance, namely, SMrSPCr, SMrSPCs, and SMsSPCr (r, resistant; s, sensitive). Curing experiments and transduction analysis of strain MS7990 (SMr.SPCr.EMr) (EM, erythromycin) disclosed that the loci governing SM and SPC resistance are different and exist on different nontransferable plasmids (r factor), one plasmid carrying the genes governing SM resistance and another possessing the genes governing resistance to both SPC and EM. Strain MS7990 (SMr.SPCr) inactivated both drugs by adenylylation. Similarly, the SMrSPCs and SMsSPCr strains inactivated SM and SPC, respectively, by adenylylation, although the adenylylated positions of both drugs have not been established as yet. The adenylylated SM in staphylococci was shown to be different from 3″-adenylyl-SM, indicating the possibility of the existence of a different enzyme from SM3″-adenylyl transferase demonstrated in Escherichia coli strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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