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. 1975 Mar;7(3):285–288. doi: 10.1128/aac.7.3.285

Phosphonoacetic Acid in the Treatment of Experimental Herpes Simplex Keratitis

Douglas D Gerstein 1, Chandler R Dawson 1, Jang O Oh 1
PMCID: PMC429125  PMID: 1137379

Abstract

In a rabbit model of herpes simplex corneal ulceration, 5% phosphonoacetic acid solution or ophthalmic ointment suppressed clinical disease and virus replication. The effect of 5% phosphonoacetic acid ointment was equivalent to that of 0.5% idoxuridine ointment in the treatment of this established herpetic eye infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dawson C., Togni B., Moore T. E., Jr Structural changes in chronic herpetic keratitis. Studied by light and electron microscopy. Arch Ophthalmol. 1968 Jun;79(6):740–747. doi: 10.1001/archopht.1968.03850040742016. [DOI] [PubMed] [Google Scholar]
  2. Inglot A. D., Kochman M., Mastalerz P. Antiviral activity of p-nitrobenzylphosphonic acid. Nature. 1965 Aug 14;207(998):784–785. doi: 10.1038/207784a0. [DOI] [PubMed] [Google Scholar]
  3. Inglot A. D., Kochman M., Mastalerz P., Pelczarska A. Peculiarities of the antiviral action of dibenzylphosphinic acid. Acta Virol. 1967 May;11(3):199–205. [PubMed] [Google Scholar]
  4. Lanier J. D., Whitcher J. P., Dawson C. R., Oh J. O. Proflavine and light in the treatment of experimental herpetic ocular infections. Antimicrob Agents Chemother. 1974 Nov;6(5):613–619. doi: 10.1128/aac.6.5.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Oh J. O. Enhancement of virus multiplication and interferon production by cortisone in ocular herpesvirus infection. J Immunol. 1970 Jun;104(6):1359–1363. [PubMed] [Google Scholar]
  6. SOOD N. N., MARMION V. J. SUPERFICIAL HERPETIC KERATITIS TREATED WITH 5-IODO-2'-DEOXYURIDINE. Br J Ophthalmol. 1964 Nov;48:609–614. doi: 10.1136/bjo.48.11.609. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Shipkowitz N. L., Bower R. R., Appell R. N., Nordeen C. W., Overby L. R., Roderick W. R., Schleicher J. B., Von Esch A. M. Suppression of herpes simplex virus infection by phosphonoacetic acid. Appl Microbiol. 1973 Sep;26(3):264–267. doi: 10.1128/am.26.3.264-267.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]

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