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. 1975 May;7(5):661–665. doi: 10.1128/aac.7.5.661

Animal Model for Determining the No-Effect Level of an Antimicrobial Drug on Drug Resistance in the Lactose-Fermenting Enteric Flora

Larry D Rollins 1, Stuart A Gaines 1, Dorothy W Pocurull 1, H Dwight Mercer 1
PMCID: PMC429199  PMID: 1147595

Abstract

Mature beagles were fed a ground-meal diet containing 0, 2, or 10 μg of oxytetracycline per g for 44 days. The 10-μg/g diet resulted in a shift from a predominantly drug-susceptible population of enteric lactose-fermenting organisms to a multiply antibiotic-resistant population which peaked at 78% resistant organisms. Since a shift to drug-resistant organisms did not occur in the group fed 2 μg/g, the level of oxytetracycline that results in increased incidence of antibiotic resistance lies between 2 and 10 μg/g in this dog model. Rats and hamsters fed diets containing oxytetracycline (10 μg/g or greater) or dihydrostreptomycin (10 μg/g), and provided suspensions of drug-susceptible Escherichia coli, did not develop a population of antibiotic-resistant organisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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