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. 1975 Jun;7(6):788–792. doi: 10.1128/aac.7.6.788

Possible Mechanism of Decreased Susceptibility of Neisseria gonorrhoeae to Penicillin

William Rodriguez 1, Arthur K Saz 1
PMCID: PMC429227  PMID: 808158

Abstract

By use of 14C-labeled benzyl penicillin, it has been established that β-lactamases and/or acylases play no role in the resistance of Neisseria gonorrhoeae to penicillin. It has been found, however, that very susceptible strains of the organisms (minimal inhibitory concentration, 0.008 μg/ml) bind 10 to 15 times as much penicillin as do moderately to highly resistant strains of the gonoccoccus (minimal inhibitory concentration, 0.125 to 2.0 μg/ml). It is postulated that this degree of change in binding components of the whole cell and whole cytoplasmic membrane is sufficient to account for the decreased susceptibility of the organism to penicillin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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