Abstract
A synergistic in vitro bactericidal effect of combinations of chloramphenicol and beta-lactams on strains of Enterobacteriaceae is described. The synergism is seen with strains which are resistant to the beta-lactam and is due to chloramphenicol-induced inhibition of beta-lactamase production.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- CHABBERT Y. Une technique nouvelle d'étude de l'action bactéricide des associations d'antibiotiques: le transfert sur cellophane. Ann Inst Pasteur (Paris) 1957 Sep;93(3):289–299. [PubMed] [Google Scholar]
- CITRI N. DETERMINATION OF PENICILLINASE ACTIVITY. Methods Med Res. 1964;10:221–232. [PubMed] [Google Scholar]
- Cluzel R., Michel J., Cluzel M., Sirot J. Les modalités de la diffusion en gélose des antibiotiques dans la disposition en croix dérivée du transfert sur cellophane. C R Seances Soc Biol Fil. 1970;164(4):807–812. [PubMed] [Google Scholar]
- Finland M. Changing ecology of bacterial infections as related to antibacterial therapy. J Infect Dis. 1970 Nov;122(5):419–431. doi: 10.1093/infdis/122.5.419. [DOI] [PubMed] [Google Scholar]
- GARROD L. P., WATERWORTH P. M. Methods of testing combined antibiotic bactericidal action and the significance of the results. J Clin Pathol. 1962 Jul;15:328–338. doi: 10.1136/jcp.15.4.328. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldner M., Glass D. G., Fleming P. C. Characteristics of Aerobacter beta-lactamase. Can J Microbiol. 1968 Feb;14(2):139–145. doi: 10.1139/m68-023. [DOI] [PubMed] [Google Scholar]
- Kabins S. A., Nathan C. R., Cohen S. R factor-mediated resistance to gentamicin in a clinical isolate of Escherichia coli. J Infect Dis. 1971 Dec;124 (Suppl):S65–S69. doi: 10.1093/infdis/124.supplement_1.s65. [DOI] [PubMed] [Google Scholar]
- Luboshitzky R., Sacks T., Michel J. Bactericidal effect of combinations of antibiotics on Klebsiella-Enterobacter-Serratia. Chemotherapy. 1973;19(6):354–366. doi: 10.1159/000221476. [DOI] [PubMed] [Google Scholar]
- Lund M. E., Blazevic D. J., Matsen J. M. Rapid gentamicin bioassay using a multiple-antibiotic-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother. 1973 Nov;4(5):569–573. doi: 10.1128/aac.4.5.569. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MANTEN A., WISSE M. J. Antagonism between antibacterial drugs. Nature. 1961 Nov 18;192:671–672. doi: 10.1038/192671a0. [DOI] [PubMed] [Google Scholar]
- Michel J., Luboshitzky R., Sacks T. Bactericidal effect of combinations of nalidixic acid and various antibiotics on Enterobacteriaceae. Antimicrob Agents Chemother. 1973 Sep;4(3):201–204. doi: 10.1128/aac.4.3.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Onishi H. R., Daoust D. R., Zimmerman S. B., Hendlin D., Stapley E. O. Cefoxitin, a semisynthetic cephamycin antibiotic: resistance to beta-lactamase inactivation. Antimicrob Agents Chemother. 1974 Jan;5(1):38–48. doi: 10.1128/aac.5.1.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seneca H. Drug susceptibility-resistance pattern of gram-negative uropathogens to seven cephalosporins. Am J Med Sci. 1973 Nov;266(5):381–385. doi: 10.1097/00000441-197311000-00005. [DOI] [PubMed] [Google Scholar]
- Traub W. H. In vitro activity of chloramphenicol combined with cephalothin against D-Nase-positive, multiple-antibiotic resistant strains of Staphylococcus epidermidis. Chemotherapy. 1970;15(4):234–241. doi: 10.1159/000220687. [DOI] [PubMed] [Google Scholar]
- Workman R. G., Farrar W. E., Jr Activity of penicillinase in Staphylococcus aureus as studied by the iodometric method. J Infect Dis. 1970 Apr;121(4):433–437. doi: 10.1093/infdis/121.4.433. [DOI] [PubMed] [Google Scholar]