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. 1975 Jul;8(1):15–17. doi: 10.1128/aac.8.1.15

Incorporation of Double-Labeled l-Cystine and dl-Valine in Penicillin

P Adriaens 1, H Vanderhaeghe 1, B Meesschaert 1, H Eyssen 1
PMCID: PMC429252  PMID: 809001

Abstract

l-[3,3′-3H]cystine was incorporated into penicillin with retention of one tritium. This result can be explained by β-lactam formation through ring closure between C3 of cysteine and NH of valine. No radioactivity of dl-[2,3-3H]valine was incorporated into penicillin. The loss of isotope at C2 occurs during the inversion of configuration. The loss of label at C3 is discussed in terms of possible intermediates for the formation of the thiazolidine ring of penicillin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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