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. 1975 Aug;8(2):220–221. doi: 10.1128/aac.8.2.220

Concentration of Clindamycin in Human Bone

Peter Nicholas , Burt R Meyers , Roger N Levy , Shalom Z Hirschman *
PMCID: PMC429291  PMID: 1180546

Abstract

Thirty patients undergoing total hip replacement received clindamycin beginning the day before surgery. Mean clindamycin concentrations during surgery were 7.33 ± 3.37 μg/ml in serum and 2.63 ± 1.76 μg/g in bone; mean ratio of bone-serum concentration was 0.40 ± 0.30.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Charnley J. Arthroplasty of the hip. A new operation. Lancet. 1961 May 27;1(7187):1129–1132. doi: 10.1016/s0140-6736(61)92063-3. [DOI] [PubMed] [Google Scholar]
  2. Kolczun M. C., Nelson C. L., McHenry M. C., Gavan T. L., Pinovich P. Antibiotic concentrations in human bone. A preliminary report. J Bone Joint Surg Am. 1974 Mar;56(2):305–310. [PubMed] [Google Scholar]
  3. Norden C. W. Experimental osteomyelitis. II. Therapeutic trials and measurement of antibiotic levels in bone. J Infect Dis. 1971 Dec;124(6):565–571. doi: 10.1093/infdis/124.6.565. [DOI] [PubMed] [Google Scholar]

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