Abstract
Various fatty acids of branched nature possess fungistatic and bacteriostatic properties. Some of these, particularly those of iso-configuration, strongly enhance the effect of conventional antimicrobial agents that act inside the cell membrane. A relation between this biological effect and the collapse properties of the corresponding monomolecular surface film on water has been observed. In this work, a series of fatty acids with a slightly smaller end group than iso-propyl, the ω-cyclopropane fatty acids, as well as one possessing a somewhat larger end group, the neo-branched fatty acids, have been examined. The ω-cyclopropane fatty acids were found to be more fungistatic than the iso-acids studied earlier. Furthermore, both cyclopropane and neo-fatty acids of short chain lengths exhibited synergistic effects in combination with tetramethylthiuramdisulfide.
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- Christie W. W., Holman R. T. Mass spectrometry of lipids. I. Cyclopropane fatty acid esters. Lipids. 1966 May;1(3):176–182. doi: 10.1007/BF02531869. [DOI] [PubMed] [Google Scholar]
- Kinsky S. C. Antibiotic interaction with model membranes. Annu Rev Pharmacol. 1970;10:119–142. doi: 10.1146/annurev.pa.10.040170.001003. [DOI] [PubMed] [Google Scholar]
- Larsson K., Noren B., Odham G. Antimicrobial effect of simple lipids and its relation to surface film behaviour. I. Biochem Pharmacol. 1972 Apr 1;21(7):947–962. doi: 10.1016/0006-2952(72)90399-1. [DOI] [PubMed] [Google Scholar]
- McCloskey J. A., Law J. H. Ring location in cyclopropane fatty acid esters by a mass spectrometric method. Lipids. 1967 May;2(3):225–230. doi: 10.1007/BF02532560. [DOI] [PubMed] [Google Scholar]
- Meyer H., Holz G. G., Jr Biosynthesis of lipids by kinetoplastid flagellates. J Biol Chem. 1966 Nov 10;241(21):5000–5007. [PubMed] [Google Scholar]
- Norman A. W., Demel R. A., de Kruyff B., van Deenen L. L. Studies on the biological properties of polyene antibiotics. Evidence for the direct interaction of filipin with cholesterol. J Biol Chem. 1972 Mar 25;247(6):1918–1929. [PubMed] [Google Scholar]
- O'leary W. M. THE FATTY ACIDS OF BACTERIA. Bacteriol Rev. 1962 Dec;26(4):421–447. doi: 10.1128/br.26.4.421-447.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]