Abstract
Administration of cephalothin to normal volunteers in maximal doses of 300 mg/kg per day resulted in a combined defect of platelet function and blood coagulation. No such abnormalities were evident after infusion of cefazolin or cephapirin at a maximal dosage of 200 mg/kg per day. The observed thrombocytopathy was similar to but less severe than that induced by carbenicillin or ticarcillin and was not reflected by a prolonged bleeding time test or impaired prothrombin consumption. Moreover, it was not a consistent finding in those persons receiving cephalothin. A separate defect involving blood coagulation appeared to result from delayed fibrinogen-fibrin polymerization and was evidenced by extended values of the activated partial thromboplastin and thrombin time tests. It remains uncertain whether the abnormalities described may constitute clinically important hemostatic disorders in patients with normal renal function receiving large doses of cephalosporin antibiotics.
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Selected References
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- Bran J. L., Levison M. E., Kaye D. Clinical and in vitro evaluation of cephapirin, a new cephalosporin antibiotic. Antimicrob Agents Chemother. 1972 Jan;1(1):35–40. doi: 10.1128/aac.1.1.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown C. H., 3rd, Natelson E. A., Bradshaw M. W., Alfrey C P., Jr, Williams T. W., Jr Study of the effects of ticarcillin on blood coagulation and platelet function. Antimicrob Agents Chemother. 1975 May;7(5):652–657. doi: 10.1128/aac.7.5.652. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown C. H., 3rd, Natelson E. A., Bradshaw W., Williams T. W., Jr, Alfrey C. P., Jr The hemostatic defect produced by carbenicillin. N Engl J Med. 1974 Aug 8;291(6):265–270. doi: 10.1056/NEJM197408082910601. [DOI] [PubMed] [Google Scholar]
- Craig W. A., Welling P. G., Jackson T. C., Kunin C. M. Pharmacology of cefazolin and other cephalosporins in patients with renal insufficiency. J Infect Dis. 1973 Oct;128(Suppl):S347–S345. doi: 10.1093/infdis/128.supplement_2.s347. [DOI] [PubMed] [Google Scholar]
- Lerner P. I., Lubin A. Letter: Coagulopathy with cefazolin in uremia. N Engl J Med. 1974 Jun 6;290(23):1324–1324. doi: 10.1056/NEJM197406062902317. [DOI] [PubMed] [Google Scholar]
- Natelson E. A., Dooley D. F. Rapid determination of fibrinogen by thrombokinetics. Am J Clin Pathol. 1974 Jun;61(6):828–833. doi: 10.1093/ajcp/61.6.828. [DOI] [PubMed] [Google Scholar]
- Natelson E. A., Shapiro D., Smith D. F. Detection of mild factor VIII Deficiency by thrombokinetics. Am J Clin Pathol. 1975 Jul;64(1):95–100. doi: 10.1093/ajcp/64.1.95. [DOI] [PubMed] [Google Scholar]