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. 1976 Jun;9(6):903–907. doi: 10.1128/aac.9.6.903

Mechanism of Action of Miconazole: Labilization of Rat Liver Lysosomes In Vitro by Miconazole

K H Sreedhara Swamy 1, Aruna Joshi 1, G Ramananda Rao 1
PMCID: PMC429648  PMID: 7188

Abstract

Miconazole, a potent antifungal agent, labilizes rat liver lysosomes. Its labilizing effect is followed by measuring the release of lysosomal hydrolases, namely, acid phosphatase, β-glucuronidase, and arylsulfatase A. The effect of miconazole is concentration dependent in the range of 10−5 to 1.2 × 10−4 M. However, at higher concentrations, miconazole inhibits enzyme release but does not inhibit enzyme activities per se. The effect of miconazole depends on the drug/lysosome ratio and is influenced by the pH of the incubation media, being minimal at alkaline pH. Membrane-active drugs such as nystatin, 2-phenethyl-alcohol, hexachlorophene, and digitonin have been compared with miconazole for their lysosome-labilizing action. The effect of miconazole on the lysosomal membrane is confirmed by a decrease in turbidity of the lysosomal suspension.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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