Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1976 Jun;9(6):945–950. doi: 10.1128/aac.9.6.945

Enzymatic Modification of Aminoglycoside Antibiotics: a New 6′-N-Acetylating Enzyme from a Pseudomonas aeruginosa Isolate

M Haas †, S Biddlecome †, J Davies *, C E Luce †, P J L Daniels †
PMCID: PMC429655  PMID: 820249

Abstract

We describe an aminoglycoside 6′-N-acetyltransferase, isolated from Pseudomonas aeruginosa, that exhibits a novel substrate profile characterized by markedly reduced activity towards butirosin and amikacin.

Full text

PDF
949

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Basak K., Majumdar S. K. Utilization of carbon and nitrogen sources by Streptomyces kanamyceticus for kanamycin production. Antimicrob Agents Chemother. 1973 Jul;4(1):6–10. doi: 10.1128/aac.4.1.6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Benveniste R., Davies J. Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor. Biochemistry. 1971 May 11;10(10):1787–1796. doi: 10.1021/bi00786a009. [DOI] [PubMed] [Google Scholar]
  3. Haas M. J., Dowding J. E. Aminoglycoside-modifying enzymes. Methods Enzymol. 1975;43:611–628. doi: 10.1016/0076-6879(75)43124-x. [DOI] [PubMed] [Google Scholar]
  4. Kawabe H., Kondo S., Umezawa H., Mitsuhashi S. R factor-mediated aminoglycoside antibiotic resistance in Pseudomonas aeruginosa: a new aminoglycoside 6'-N-acetyltransferase. Antimicrob Agents Chemother. 1975 May;7(5):494–499. doi: 10.1128/aac.7.5.494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Le Goffic F., Martel A. La résistance aux aminosides provoquée par une isoenzyme la kanamycine acétyltransférase. Biochimie. 1974;56(6-7):893–897. doi: 10.1016/s0300-9084(74)80512-2. [DOI] [PubMed] [Google Scholar]
  6. Minshew B. H., Holmes R. K., Sanford J. P., Baxter C. R. Transferrable resistance to tobramycin in Klebsiella pneumoniae and Enterobacter cloacae associated with enzymatic acetylation of tobramycin. Antimicrob Agents Chemother. 1974 Oct;6(4):492–497. doi: 10.1128/aac.6.4.492. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Reimann H., Cooper D. J., Mallams A. K., Jaret R. S., Yehaskel A., Kugelman M., Vernay H. F., Schumacher D. The structure of sisomicin, a novel unsaturated aminocyclitol antibiotic from Micromonospora inyoensis. J Org Chem. 1974 May 31;39(11):1451–1457. doi: 10.1021/jo00924a001. [DOI] [PubMed] [Google Scholar]
  8. Umezawa H., Okanishi M., Utahara R., Maeda K., Kondo S. Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli. J Antibiot (Tokyo) 1967 Jul;20(3):136–141. [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES