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. 1976 Aug;10(2):307–317. doi: 10.1128/aac.10.2.307

Comparative Pharmacokinetics and Metabolism of Cephapirin in Laboratory Animals and Humans

B E Cabana a,1, D R Van Harken a, G H Hottendorf a
PMCID: PMC429740  PMID: 984774

Abstract

Comparative drug disposition studies in mice, rats, dogs, and humans indicate that cephapirin, a new semisynthetic cephalosporin antibiotic that exhibits broad-spectrum antimicrobial activity, is metabolized to desacetylcephapirin in these species. Pharmacokinetic analyses of the concentrations of cephapirin and desacetylcephapirin in plasma and urine reveal that the rate and extent of deacetylation decreases from rodents to dogs to humans. The kinetic analyses also suggest that the kidney performs a role not only in the excretion but also in the metabolism of cephapirin to desacetylcephapirin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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