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. 1976 Oct;10(4):677–681. doi: 10.1128/aac.10.4.677

In Vitro Susceptibility of Gentamicin-Resistant Enterobacteriaceae and Pseudomonas aeruginosa to Netilmicin and Selected Aminoglycoside Antibiotics

Richard D Meyer *, Linda L Kraus †, Karen A Pasiecznik †
PMCID: PMC429813  PMID: 825036

Abstract

Netilmicin (Sch 20569), a semisynthetic aminoglycoside related to gentamicin C1a, was evaluated in vitro in agar dilution testing against 224 different clinical isolates of gentamicin-resistant Enterobacteriaceae and Pseudomonas aeruginosa in parallel with amikacin, gentamicin, sisomicin, and tobramycin. Netilmicin showed a very high degree of activity against gentamicin-resistant organisms, but amikacin was more active in vitro, particularly against Providencia stuartii and P. aeruginosa. Sisomicin and tobramycin were consistently less active than either netilmicin or amikacin. Netilmicin was bactericidal in broth testing against P. aeruginosa. Netilmicin showed a greater difference between results with agar and broth dilution testing than did amikacin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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