Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1976 Oct;10(4):733–735. doi: 10.1128/aac.10.4.733

Concentration of Cefamandole in Serum Interstitial Fluid, Bile, and Urine

N G Waterman *, H U Eickenberg *, L Scharfenberger *
PMCID: PMC429822  PMID: 984808

Abstract

Cefamandole readily diffuses from the serum into soft tissue interstitial fluid. The rate of diffusion differs little from that of cephalothin. The concentrations of antibiotic were greater in bile and urine during the entire period of study than is necessary to kill susceptible pathogenic bacteria present in these fluids.

Full text

PDF
735

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bodey G. P., Weaver S. In vitro studies of cefamandole. Antimicrob Agents Chemother. 1976 Mar;9(3):452–457. doi: 10.1128/aac.9.3.452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Calnan J. S., Pflug J. J., Chisholm G. D., Taylor L. M. Pathophysiology of tissue fluid. Proc R Soc Med. 1972 Aug;65(8):715–719. [PMC free article] [PubMed] [Google Scholar]
  3. Chisholm G. D., Waterworth P. M., Calnan J. S., Garrod L. P. Concentration of antibacterial agents in interstitial tissue fluid. Br Med J. 1973 Mar 10;1(5853):569–573. doi: 10.1136/bmj.1.5853.569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Eickenberg H. U., Waterman N. G., Scharfenberger L. Concentration of antibiotics in renal interstitial fluid: an experimental model. Urol Res. 1975 Dec 30;3(4):165–167. doi: 10.1007/BF00261952. [DOI] [PubMed] [Google Scholar]
  5. Eickenberg H. U., Waterman N. G., Scharfenberger L. Renal interstitial fluid, urine, and serum antibiotic concentration. Surg Forum. 1975;26:589–591. [PubMed] [Google Scholar]
  6. Eykyn S., Jenkins C., King A., Phillips I. Antibacterial activity of cefamandole, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cephalexin. Antimicrob Agents Chemother. 1973 Jun;3(6):657–661. doi: 10.1128/aac.3.6.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Neu H. C. Cefamandole, a cephalosporin antibiotic with an unusually wide spectrum of activity. Antimicrob Agents Chemother. 1974 Aug;6(2):177–182. doi: 10.1128/aac.6.2.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Sabath L. D., Casey J. I., Ruch P. A., Stumpf L. L., Finland M. Rapid microassay for circulating nephrotoxic antibiotics. Antimicrob Agents Chemother (Bethesda) 1970;10:83–90. doi: 10.1128/AAC.10.1.83. [DOI] [PubMed] [Google Scholar]
  9. Waterman N. G., Kastan L. B. Interstitial fluid and serum antibiotic concentrations. Arch Surg. 1972 Aug;105(2):192–196. doi: 10.1001/archsurg.1972.04180080046008. [DOI] [PubMed] [Google Scholar]
  10. Waterman N. G., Raff M. J., Scharfenberger L., Barnwell P. A. Antibiotic concentrations in hepatic interstitial and wound fluid. Surg Gynecol Obstet. 1976 Feb;142(2):235–238. [PubMed] [Google Scholar]
  11. Waterman N. G., Raff M. J., Scharfenberger L., Barnwell P. A. Protein binding and concentrations of cephaloridine and cefazolin in serum and interstitial fluid of dogs. J Infect Dis. 1976 Jun;133(6):642–647. doi: 10.1093/infdis/133.6.642. [DOI] [PubMed] [Google Scholar]
  12. Waterman N., Scharfenberger L., Raff M. J. Rate of binding of antibiotics to canine serum protein. Antimicrob Agents Chemother. 1974 Mar;5(3):294–295. doi: 10.1128/aac.5.3.294. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES