Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1977 Sep;12(3):335–338. doi: 10.1128/aac.12.3.335

Biotransformation of Sisomicin to Gentamicin C2b

B K Lee 1, J V Bailey 1, R G Condon 1, J A Marquez 1, G H Wagman 1, M J Weinstein 1
PMCID: PMC429914  PMID: 907326

Abstract

Sisomicin was transformed to gentamicin C2b by Micromonospora rhodorangea NRRL 5326. The mechanisms involved in the biotransformation are the 6′-N-methylation and the (4′-5′)-reduction. The progression of the methylation was followed by the isotope technique, but the reduction reaction was not monitored.

Full text

PDF
335

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Daniels P. J., Jaret R. S., Nagabhushan T. L., Turner W. N. The structure of antibiotic G-52, a new aminocyclitol-aminoglycoside antibiotic produced by Micromonospora zionensis. J Antibiot (Tokyo) 1976 May;29(5):488–491. doi: 10.7164/antibiotics.29.488. [DOI] [PubMed] [Google Scholar]
  2. Daniels P. J., Luce C., Nagabhushan T. L. The gentamicin antibiotics. 6. Gentamicin C2b, an aminoglycoside antibiotic produced by Micromonospora purpurea mutant JI-33. J Antibiot (Tokyo) 1975 Jan;28(1):35–41. doi: 10.7164/antibiotics.28.35. [DOI] [PubMed] [Google Scholar]
  3. Lee B. K., Condon R. G., Wagman G. H., Byrne K., Schaffner C. Incorporation of L-methionine-methyl-14C into gentamicins. II. Large-scale preparation of methyl-14C-gentamicins. J Antibiot (Tokyo) 1974 Nov;27(11):822–825. doi: 10.7164/antibiotics.27.822. [DOI] [PubMed] [Google Scholar]
  4. Lee B. K., Testa R. T., Wagman G. H., Liu C. M., McDaniel L., Schaffner C. Incorporation of L-methionine-methyl-14C into gentamicins. J Antibiot (Tokyo) 1973 Dec;26(12):728–731. doi: 10.7164/antibiotics.26.728. [DOI] [PubMed] [Google Scholar]
  5. Marquez J. A., Wagman G. H., Testa R. T., Waitz J. A., Weinstein M. J. A new broad spectrum aminoglycoside antibiotic, G-52, produced by Micromonospora zionensis. J Antibiot (Tokyo) 1976 May;29(5):483–487. doi: 10.7164/antibiotics.29.483. [DOI] [PubMed] [Google Scholar]
  6. Okachi R., Kawamoto I., Takasawa S., Yamamoto M., Sato S. A new antibiotic XK-62-2 (Sagamicin). I. Isolation, physicochemical and antibacterial properties. J Antibiot (Tokyo) 1974 Oct;27(10):793–800. doi: 10.7164/antibiotics.27.793. [DOI] [PubMed] [Google Scholar]
  7. Testa R. T., Tilley B. C. Biotransformation, a new approach to aminoglycoside biosynthesis: II. Gentamicin. J Antibiot (Tokyo) 1976 Feb;29(2):140–146. doi: 10.7164/antibiotics.29.140. [DOI] [PubMed] [Google Scholar]
  8. Wagman G. H., Testa R. T., Marquez J. A., Weinstein M. J. Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: fermentation, isolation, and preliminary characterization. Antimicrob Agents Chemother. 1974 Aug;6(2):144–149. doi: 10.1128/aac.6.2.144. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES