Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1977 Oct;12(4):513–517. doi: 10.1128/aac.12.4.513

Plasmid-Mediated Resistance to Gentamicin in Staphylococcus aureus

David O Wood 1, Mary Jo Carter 2, Gary K Best 1
PMCID: PMC429956  PMID: 921246

Abstract

Two strains isolated from a recent outbreak of infections by gentamicin-resistant Staphylococcus aureus were examined to determine whether genetic control of this resistance is plasmid or chromosomally mediated. Curing techniques indicated a plasmid location in both strains. Physical isolation and characterization of the plasmid deoxyribonucleic acid from one strain revealed that the determinant for gentamicin resistance resides on a 50S plasmid.

Full text

PDF
517

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asheshov E. H. Loss of antibiotic resistance in Staphylococcus aureus resulting from growth at high temperature. J Gen Microbiol. 1966 Mar;42(3):403–410. doi: 10.1099/00221287-42-3-403. [DOI] [PubMed] [Google Scholar]
  2. Best G. K., Best N. H., Koval A. V. Evidence for participation of autolysins in bactericidal action of oxacillin on Staphylococcus aureus. Antimicrob Agents Chemother. 1974 Dec;6(6):825–830. doi: 10.1128/aac.6.6.825. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Best G. K., Koval A. V., Best N. H. Susceptibility of clinical isolates of Staphylococcus aureus to killing by oxacillin. Can J Microbiol. 1975 Nov;21(11):1692–1697. doi: 10.1139/m75-248. [DOI] [PubMed] [Google Scholar]
  4. CRAWFORD L. V., BLACK P. H. THE NUCLEIC ACID OF SIMIAN VIRUS 40. Virology. 1964 Nov;24:388–392. doi: 10.1016/0042-6822(64)90176-x. [DOI] [PubMed] [Google Scholar]
  5. Dowding J. E. Mechanisms of gentamicin resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 1977 Jan;11(1):47–50. doi: 10.1128/aac.11.1.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Johnston J. H., Richmond M. H. The increased rate of loss of penicillinase plasmids from Staphylococcus aureus in the presence of rifampicin. J Gen Microbiol. 1970 Jan;60(1):137–139. doi: 10.1099/00221287-60-1-137. [DOI] [PubMed] [Google Scholar]
  7. Kensit J. G., Shanson D. C. Gentamicin resistance in methicillin-sensitive and resistant Staphyococcus aureus. J Antimicrob Chemother. 1976 Sep;2(3):311–312. doi: 10.1093/jac/2.3.311. [DOI] [PubMed] [Google Scholar]
  8. Lacey R. W. Antibiotic resistance plasmids of Staphylococcus aureus and their clinical importance. Bacteriol Rev. 1975 Mar;39(1):1–32. doi: 10.1128/br.39.1.1-32.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mayhall C. G., Medoff G., Marr J. J. Variation in the susceptibility of strains of Staphylococcus aureus to oxacillin, cephalothin, and gentamicin. Antimicrob Agents Chemother. 1976 Oct;10(4):707–712. doi: 10.1128/aac.10.4.707. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Novick R. P., Bouanchaud D. The problems of drug-resistant pathogenic bacteria. Extrachromosomal nature of drug resistance in Staphylococcus aureus. Ann N Y Acad Sci. 1971 Jun 11;182:279–294. doi: 10.1111/j.1749-6632.1971.tb30664.x. [DOI] [PubMed] [Google Scholar]
  11. Porthouse A., Brown D. F., Smith R. G., Rogers T. Gentamicin resistance in Staphylococcus aureus. Lancet. 1976 Jan 3;1(7949):20–21. doi: 10.1016/s0140-6736(76)92912-3. [DOI] [PubMed] [Google Scholar]
  12. Soussy C. J., Bouanchaud D. H., Fouace J., Dublanchet A., Duval J. A gentamycin resistance plasmid in Staphylococcus aureus. Ann Microbiol (Paris) 1975 Jul-Aug;126B(1):91–94. [PubMed] [Google Scholar]
  13. Speller D. C., Raghunath D., Stephens M., Viant A. C., Reeves D. S., Wilkinson P. J., Broughall J. M., Holt H. A. Epidemic infection by a gentamicin-resistant Staphylococcus aureus in three hospitals. Lancet. 1976 Feb 28;1(7957):464–466. doi: 10.1016/s0140-6736(76)91485-9. [DOI] [PubMed] [Google Scholar]
  14. Warren R. E., Roberts S. O. Letter: Gentamicin-resistant Staphylococci. Lancet. 1976 Mar 6;1(7958):543–544. doi: 10.1016/s0140-6736(76)90336-6. [DOI] [PubMed] [Google Scholar]
  15. Watanakunakorm C., Glotzbecker C. Enhancement of the effects of anti-staphylococcal antibiotics by aminoglycosides. Antimicrob Agents Chemother. 1974 Dec;6(6):802–806. doi: 10.1128/aac.6.6.802. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES