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. 1976 Apr;73(4):1014–1018. doi: 10.1073/pnas.73.4.1014

Bovine leukemia virus: an exogenous RNA oncogenic virus.

R Kettmann, D Portetelle, M Mammerickx, Y Cleuter, D Dekegel, M Galoux, J Ghysdael, A Burny, H Chantrenne
PMCID: PMC430190  PMID: 57616

Abstract

Short-term cultures of bovine leukemic lymphocytes release virus particles with biochemical properties of RNA oncogenic viruses. These particles, tentatively called bovine leukemia virus (BLV), have a high molecular weight RNA-reverse transcriptase complex and a density of 1.155 g/ml in sucrose solutions. Molecular hybridizations between BLV/[3H]cDNA and several viral RNAs show that BLV is not related to Mason-Pfizer monkey virus, simian sarcoma associated virus, feline leukemia virus, or avian myeloblastosis virus. These results were confirmed by hybridization between BLV 70S RNA and [3H]cDNA synthesized in the various viruses tested. The high preference of BLV reverse transciptase for Mg++ as the divalent cation suggests that BLV might be an atypical mammalian leukemogenic "type C" virus. DNA-DNA hybridization studies using BLV [3H]cDNA as a probe strongly suggest that the DNA of bovine leukemic cells contains viral sequences that cannot be detected in normal bovine DNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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