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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1976 Oct;73(10):3661–3665. doi: 10.1073/pnas.73.10.3661

Structural studies on protein products of murine chromosome 17: partial amino acid sequence of an H-2Kb molecule.

J D Capra, E S Vitetta, D G Klapper, J W Uhr, J Klein
PMCID: PMC431178  PMID: 1068479

Abstract

By use of single internal radiolabels, 17 of the NH2-terminal 27 amino acids of the murine H-2Kb molecule have been assigned. When the amino acid sequence is compared to that of the murine H-2Kk molecule, there is a minimum of six amino acid differences in 19 positions. This high degree of structural diversity confirms, at the level of amino acid sequence, the known polymorphism of the murine H-2 complex. Significant primary str-ctural homology is evident when the murine H-2Kk and H-2Kb sequences are compared to the recently reported partial amino acid sequences of human transplantation antigens. There is modest homology with beta2-mictoglobulin and immunoglobulins, but the available sequence information is insufficient for a satisfactory evaluation of its significance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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