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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1977 Dec;74(12):5421–5425. doi: 10.1073/pnas.74.12.5421

High resolution two-dimensional electrophoresis of human plasma proteins.

L Anderson, N G Anderson
PMCID: PMC431746  PMID: 271964

Abstract

The two-dimensional electrophoretic technique of O'Farrell has been adapted to the analysis of human plasma proteins, and 30 polypeptides have been identified in the pattern produced. Genetic variants involving charge (isoelectric point) or size (molecular weight in the presence of sodium dodecyl sulfate) changes should be routinely detectable in at least 20 proteins at once, facilitating studies of human mutation rates.

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Selected References

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