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. 1977 Dec;74(12):5739–5743. doi: 10.1073/pnas.74.12.5739

Interspecies radioimmunoassay for the major structural proteins of primate type-D retroviruses.

D Colcher, Y A Teramoto, J Schlom
PMCID: PMC431869  PMID: 202962

Abstract

A competition radioimmunoassay has been developed in which type-D retroviruses from three primate species compete. The assay utilizes the major structural protein (36,000 daltons) of the endogenous squirrel monkey retrovirus and antisera directed against the major structural protein (27,000 daltons) of the Mason-Pfizer monkey virus isolated from rhesus monkeys. Purified preparations of both viruses grown in heterologous cells, as well as extracts of heterologous cells infected with squirrel monkey retrovirus or Mason-Pfizer monkey virus, compete completely in the assay. Addition of an endogenous virus of the langur monkey also results in complete blocking. No blocking in the assay is observed with type-C baboon viruses, woolly monkey virus, and gibbon virus. Various other type-C and type-B viruses also showed no reactivity. An interspecies assay has thus been developed that recognizes the type-D retroviruses from both Old World monkey (rhesus and langur) and New World monkey (squirrel) species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahmed M., Schidlovsky G., Korol W., Vidrine G., Cicmanec J. L. Occurrence of Mason-Pfizer monkey virus in healthy rhesus monkeys. Cancer Res. 1974 Dec;34(12):3504–3508. [PubMed] [Google Scholar]
  2. BEARD J. W. AVIAN VIRUS GROWTHS AND THEIR ETIOLOGIC AGENTS. Adv Cancer Res. 1963;7:1–127. doi: 10.1016/s0065-230x(08)60982-3. [DOI] [PubMed] [Google Scholar]
  3. Chopra H. C., Mason M. M. A new virus in a spontaneous mammary tumor of a rhesus monkey. Cancer Res. 1970 Aug;30(8):2081–2086. [PubMed] [Google Scholar]
  4. Colcher D., Heberling R. L., Kalter S. S., Schlom J. Squirrel monkey retrovirus: an endogenous virus of a new world primate. J Virol. 1977 Aug;23(2):294–301. doi: 10.1128/jvi.23.2.294-301.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dalton A. J., Melnick J. L., Bauer H., Beaudreau G., Bentvelzen P., Bolognesi D., Gallo R., Graffi A., Haguenau F., Heston W. The case for a family of reverse transcriptase viruses: Retraviridae. Intervirology. 1974;4(4):201–206. doi: 10.1159/000149963. [DOI] [PubMed] [Google Scholar]
  6. Diaz-Ruiz J. R., Kaper J. M. Cucumber mosaic virus-associated RNA 5. III. Little nucleotide sequence homology between CARNA 5 and helper RNA. Virology. 1977 Jul 1;80(1):204–213. doi: 10.1016/0042-6822(77)90393-2. [DOI] [PubMed] [Google Scholar]
  7. Drohan W., Colcher D., Schochetman G., Schlom J. Distribution of Mason-Pfizer virus-specific sequences in the DNA of primates. J Virol. 1977 Jul;23(1):36–43. doi: 10.1128/jvi.23.1.36-43.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. East J. L., Knesek J. E., Chan J. C., Dmochowski L. Quantitative nucleotide sequence relationships of mammalian RNA tumor viruses. J Virol. 1975 Jun;15(6):1396–1408. doi: 10.1128/jvi.15.6.1396-1408.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Goldberg R. J., Levin R., Parks W. P., Scolnick E. M. Quantitative analysis of the rescue of RNA sequences by mammalian type C viruses. J Virol. 1975 Jan;17(1):43–50. doi: 10.1128/jvi.17.1.43-50.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Heberling R. L., Barker S. T., Kalter S. S., Smith G. C., Helmke R. J. Oncornavirus: isolation from a squirrel monkey (Saimiri sciureus) lung culture. Science. 1977 Jan 21;195(4275):289–292. doi: 10.1126/science.63993. [DOI] [PubMed] [Google Scholar]
  11. Hino S., Tronick S. R., Heberling R. L., Kalter S. S., Hellman A., Aaronson S. A. Endogenous New World primate retrovirus: interspecies antigenic determinants shared with the major structural protein of type-D RNA viruses of Old World monkeys. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5734–5738. doi: 10.1073/pnas.74.12.5734. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kalter S. S., Helmke R. J., Panigel M., Heberling R. L., Felsburg P. J., Axelrod L. R. Observations of apparent C-type particles in baboon (Papio cynocephalus) placentas. Science. 1973 Mar 30;179(4080):1332–1333. doi: 10.1126/science.179.4080.1332. [DOI] [PubMed] [Google Scholar]
  13. Kawakami T. G., Huff S. D., Buckley P. M., Dungworth D. L., Synder S. P., Gilden R. V. C-type virus associated with gibbon lymphosarcoma. Nat New Biol. 1972 Feb 9;235(58):170–171. doi: 10.1038/newbio235170a0. [DOI] [PubMed] [Google Scholar]
  14. Kramarsky B., Sarkar N. H., Moore D. H. Ultrastructural comparison of a virus from a Rhesus-monkey mammary carcinoma with four oncogenic RNA viruses. Proc Natl Acad Sci U S A. 1971 Jul;68(7):1603–1607. doi: 10.1073/pnas.68.7.1603. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  16. Lieber M. M., Benveniste R. E., Sherr C. J., Todaro G. J. Isolation of a type C virus (FS-1) from the European Wildcat (Felis sylvestris). Virology. 1975 Jul;66(1):117–127. doi: 10.1016/0042-6822(75)90183-x. [DOI] [PubMed] [Google Scholar]
  17. McAllister R. M., Nicolson M., Gardner M. B., Rongey R. W., Rasheed S., Sarma P. S., Huebner R. J., Hatanaka M., Oroszlan S., Gilden R. V. C-type virus released from cultured human rhabdomyosarcoma cells. Nat New Biol. 1972 Jan 5;235(53):3–6. doi: 10.1038/newbio235003a0. [DOI] [PubMed] [Google Scholar]
  18. Nelson-Rees W. A., Owens R. B., Arnstein P., Kniazeff A. J. Source, alterations, characteristics and use of a new dog cell line (Cf2Th). In Vitro. 1976 Oct;12(10):665–669. doi: 10.1007/BF02797468. [DOI] [PubMed] [Google Scholar]
  19. Owens R. B., Hackett A. J. Tissue culture studies of mouse mammary tumor cells and associated viruses. J Natl Cancer Inst. 1972 Nov;49(5):1321–1332. [PubMed] [Google Scholar]
  20. Quintrell N., Varmus H. E., Bishop J. M., Nicholson M. O., McAllister R. M. Homologies among the nucleotide sequences of the genomes of C-type viruses. Virology. 1974 Apr;58(2):568–575. doi: 10.1016/0042-6822(74)90090-7. [DOI] [PubMed] [Google Scholar]
  21. RAUSCHER F. J. A virus-induced disease of mice characterized by erythrocytopoiesis and lymphoid leukemia. J Natl Cancer Inst. 1962 Sep;29:515–543. [PubMed] [Google Scholar]
  22. Rickard C. G., Post J. E., Noronha F., Barr L. M. A transmissible virus-induced lymphocytic leukemia of the cat. J Natl Cancer Inst. 1969 Jun;42(6):987–1014. [PubMed] [Google Scholar]
  23. Schlom J., Spiegelman S. DNA polymerase activities and nucleic acid components of virions isolated from a spontaneous mammary carcinoma from a rhesus monkey. Proc Natl Acad Sci U S A. 1971 Jul;68(7):1613–1617. doi: 10.1073/pnas.68.7.1613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Schochetman G., Boehm-Truitt M., Schlom J. Antigenic analysis of the major structural protein of the Mason-Pfizer monkey virus. J Immunol. 1976 Jul;117(1):168–173. [PubMed] [Google Scholar]
  25. Schochetman G., Fine D., Arthur L., Gilden R., Heberling R. Characterization of a retravirus isolated from squirrel monkeys. J Virol. 1977 Aug;23(2):384–393. doi: 10.1128/jvi.23.2.384-393.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Schochetman G., Kortright K., Schlom J. Mason-Pfizer monkey virus: analysis and localization of virion proteins and glycoproteins. J Virol. 1975 Nov;16(5):1208–1219. doi: 10.1128/jvi.16.5.1208-1219.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Sherr C. J., Fedele L. A., Benveniste R. E., Todaro G. J. Interspecies antigenic determinants of the reverse transcriptases and p30 proteins of mammalian type C viruses. J Virol. 1975 Jun;15(6):1440–1448. doi: 10.1128/jvi.15.6.1440-1448.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Stephenson J. R., Hino S., Garrett E. W., Aaronson S. A. Immunological cross reactivity of Mason-Pfizer monkey virus with type C RNA viruses endogenous to primates. Nature. 1976 Jun 17;261(5561):609–611. doi: 10.1038/261609a0. [DOI] [PubMed] [Google Scholar]
  29. Theilen G. H., Gould D., Fowler M., Dungworth D. L. C-type virus in tumor tissue of a woolly monkey (Lagothrix spp.) with fibrosarcoma. J Natl Cancer Inst. 1971 Oct;47(4):881–889. [PubMed] [Google Scholar]
  30. Todaro G. J., Lieber M. M., Benveniste R. E., Sherr C. J. Infectious primate type C viruses: Three isolates belonging to a new subgroup from the brains of normal gibbons. Virology. 1975 Oct;67(2):335–343. doi: 10.1016/0042-6822(75)90435-3. [DOI] [PubMed] [Google Scholar]
  31. Todaro G. J., Sherr C. J., Benveniste R. E., Lieber M. M., Melnick J. L. Type C viruses of baboons: isolation from normal cell cultures. Cell. 1974 May;2(1):55–61. doi: 10.1016/0092-8674(74)90008-7. [DOI] [PubMed] [Google Scholar]
  32. Witte O. N., Weissman I. L., Kaplan H. S. Structural characteristics of some murine RNA tumor viruses studied by lactoperoxidase iodination. Proc Natl Acad Sci U S A. 1973 Jan;70(1):36–40. doi: 10.1073/pnas.70.1.36. [DOI] [PMC free article] [PubMed] [Google Scholar]

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