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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1977 Jun;74(6):2251–2255. doi: 10.1073/pnas.74.6.2251

Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface membranes.

B Whittenberger, L Glaser
PMCID: PMC432147  PMID: 196284

Abstract

When added to a sparse culture of 3T3 cells, a surface membrane-enriched fraction from 3T3 cells inhibited the rate of DNA synthesis in a time- and concentration-dependent manner. The membrane preparation had no effect on the rate of DNA synthesis of simian virus 40-transformed 3T3 cells. A similar membrane preparation from transformed cells had a lesser inhibitory effect on 3T3 cells and no effect on transformed cells. The inhibition by membranes was reversible. The data suggest that, when added to growing 3T3 cells, 3T3 surface membranes can mimic the effect of increasing cell density on DNA synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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