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. 1975 Jun;72(6):2060–2063. doi: 10.1073/pnas.72.6.2060

Mechanism and modification of bradykinin-induced coronary vasodilation.

P Needleman, S L Key, S E Denny, P C Isakson, Marshall GROUSI, Missouri 63110
PMCID: PMC432693  PMID: 1056012

Abstract

In isolated perfused rabbit hearts, bradykinin produced a concentration-dependent decrease in coronary resistance directly associated with biosynthesis and release of prostaglandin-E-like substance. An inhibitor of bradykinin destruction (the nonapeptide SQ-20881) markedly enhanced both the coronary vasodilation and release of prostaglandin-E-like substance produced by cardiac injection of bradykinin. Indomethacin inhibited both the myocardial prostaglandin biosynthesis and the decrease in coronary resistance induced by bradykinin. The demonstration that bradykinin is a potent stimulator of prostaglandin biosynthesis in the heart has implications as to the cause of the afferent cardiovascular reflexes and pain in myocardial infarction and angina pectoris.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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