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. 1975 Jun;72(6):2084–2087. doi: 10.1073/pnas.72.6.2084

A link between streptomycin and rifampicin mutation.

S L Chakrabarti, L Gorini
PMCID: PMC432699  PMID: 1094452

Abstract

Introduction of str A mutations frequently make "male" strains of Escherichia coli permissive to bacteriophage T7; certain rif mutations reverse the permissive effect of strA mutation. Permissiveness of the strA mutation is accompanied by enhanced transcription of bacteriophage T7 genome. Introduction of the nonpermissive rif allele to the permissive strA strain reduces or abolishes the transcription of T7 genome. Thus, a link is implied in the functioning of the ribosome and the RNA polymerase (RNA nucleotidyltransferase, EC 2.7.7.6).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Breckenridge L., Gorini L. Genetic analysis of streptomycin resistance in Escherichia coli. Genetics. 1970 May;65(1):9–25. doi: 10.1093/genetics/65.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chakrabarti S., Gorini L. Growth of bacteriophages MS2 and T7 on streptomycin-resistant mutants of Escherichia coli. J Bacteriol. 1975 Feb;121(2):670–674. doi: 10.1128/jb.121.2.670-674.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DAVIS B. D., MINGIOLI E. S. Mutants of Escherichia coli requiring methionine or vitamin B12. J Bacteriol. 1950 Jul;60(1):17–28. doi: 10.1128/jb.60.1.17-28.1950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hyman R. W., Brunovskis I., Summers W. C. A biochemical comparison of the related bacteriophages T7, phiI, phiII, W31, H, and T3. Virology. 1974 Jan;57(1):189–206. doi: 10.1016/0042-6822(74)90120-2. [DOI] [PubMed] [Google Scholar]
  5. Kramer R. A., Rosenberg M., Steitz J. A. Nucleotide sequences of the 5' and 3' termini of bacteriophage T7 early messenger RNAs synthesized in vivo: evidence for sequence specificity in RNA processing. J Mol Biol. 1974 Nov 15;89(4):767–776. doi: 10.1016/0022-2836(74)90051-5. [DOI] [PubMed] [Google Scholar]
  6. LENNOX E. S. Transduction of linked genetic characters of the host by bacteriophage P1. Virology. 1955 Jul;1(2):190–206. doi: 10.1016/0042-6822(55)90016-7. [DOI] [PubMed] [Google Scholar]
  7. MAEKELAE O., MAEKELAE P. H., SOIKKELI S. SEX-SPECIFICITY OF THE BACTERIOPHAGE T7. Ann Med Exp Biol Fenn. 1964;42:188–195. [PubMed] [Google Scholar]
  8. Morrison T. G., Malamy M. H. T7 translational control mechanisms and their inhibiton by F factors. Nat New Biol. 1971 May 12;231(19):37–41. doi: 10.1038/newbio231037a0. [DOI] [PubMed] [Google Scholar]
  9. Studier F. W. Bacteriophage T7. Science. 1972 Apr 28;176(4033):367–376. doi: 10.1126/science.176.4033.367. [DOI] [PubMed] [Google Scholar]
  10. Taylor A. L., Trotter C. D. Linkage map of Escherichia coli strain K-12. Bacteriol Rev. 1972 Dec;36(4):504–524. doi: 10.1128/br.36.4.504-524.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Tocchini-Valentini G. P., Marino P., Colvill A. J. Mutant of E. coli containing an altered DNA-dependent RNA polymerase. Nature. 1968 Oct 19;220(5164):275–276. doi: 10.1038/220275a0. [DOI] [PubMed] [Google Scholar]

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