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. 1994 Mar 15;91(6):2016–2020. doi: 10.1073/pnas.91.6.2016

Hemispheric encoding/retrieval asymmetry in episodic memory: positron emission tomography findings.

E Tulving 1, S Kapur 1, F I Craik 1, M Moscovitch 1, S Houle 1
PMCID: PMC43300  PMID: 8134342

Abstract

Data are reviewed from positron emission tomography studies of encoding and retrieval processes in episodic memory. These data suggest a hemispheric encoding/retrieval asymmetry model of prefrontal involvement in encoding and retrieval of episodic memory. According to this model, the left and right prefrontal lobes are part of an extensive neuronal network that subserves episodic remembering, but the two prefrontal hemispheres play different roles. Left prefrontal cortical regions are differentially more involved in retrieval of information from semantic memory and in simultaneously encoding novel aspects of the retrieved information into episodic memory. Right prefrontal cortical regions, on the other hand, are differentially more involved in episodic memory retrieval.

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2018

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Craik F. I., Morris L. W., Morris R. G., Loewen E. R. Relations between source amnesia and frontal lobe functioning in older adults. Psychol Aging. 1990 Mar;5(1):148–151. doi: 10.1037/0882-7974.5.1.148. [DOI] [PubMed] [Google Scholar]
  2. Deutsch G., Papanicolaou A. C., Eisenberg H. M., Loring D. W., Levin H. S. CBF gradient changes elicited by visual stimulation and visual memory tasks. Neuropsychologia. 1986;24(2):283–287. doi: 10.1016/0028-3932(86)90062-x. [DOI] [PubMed] [Google Scholar]
  3. Frith C. D., Friston K. J., Liddle P. F., Frackowiak R. S. A PET study of word finding. Neuropsychologia. 1991;29(12):1137–1148. doi: 10.1016/0028-3932(91)90029-8. [DOI] [PubMed] [Google Scholar]
  4. Frith C. D., Friston K., Liddle P. F., Frackowiak R. S. Willed action and the prefrontal cortex in man: a study with PET. Proc Biol Sci. 1991 Jun 22;244(1311):241–246. doi: 10.1098/rspb.1991.0077. [DOI] [PubMed] [Google Scholar]
  5. Goldman-Rakic P. S. Topography of cognition: parallel distributed networks in primate association cortex. Annu Rev Neurosci. 1988;11:137–156. doi: 10.1146/annurev.ne.11.030188.001033. [DOI] [PubMed] [Google Scholar]
  6. Graf P., Schacter D. L. Implicit and explicit memory for new associations in normal and amnesic subjects. J Exp Psychol Learn Mem Cogn. 1985 Jul;11(3):501–518. doi: 10.1037//0278-7393.11.3.501. [DOI] [PubMed] [Google Scholar]
  7. Grasby P. M., Frith C. D., Friston K. J., Bench C., Frackowiak R. S., Dolan R. J. Functional mapping of brain areas implicated in auditory--verbal memory function. Brain. 1993 Feb;116(Pt 1):1–20. doi: 10.1093/brain/116.1.1. [DOI] [PubMed] [Google Scholar]
  8. Herscovitch P., Markham J., Raichle M. E. Brain blood flow measured with intravenous H2(15)O. I. Theory and error analysis. J Nucl Med. 1983 Sep;24(9):782–789. [PubMed] [Google Scholar]
  9. Kapur S., Craik F. I., Tulving E., Wilson A. A., Houle S., Brown G. M. Neuroanatomical correlates of encoding in episodic memory: levels of processing effect. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2008–2011. doi: 10.1073/pnas.91.6.2008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Milner B., Petrides M., Smith M. L. Frontal lobes and the temporal organization of memory. Hum Neurobiol. 1985;4(3):137–142. [PubMed] [Google Scholar]
  11. Petersen S. E., Fiez J. A. The processing of single words studied with positron emission tomography. Annu Rev Neurosci. 1993;16:509–530. doi: 10.1146/annurev.ne.16.030193.002453. [DOI] [PubMed] [Google Scholar]
  12. Petersen S. E., Fox P. T., Posner M. I., Mintun M., Raichle M. E. Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature. 1988 Feb 18;331(6157):585–589. doi: 10.1038/331585a0. [DOI] [PubMed] [Google Scholar]
  13. Petersen S. E., Fox P. T., Snyder A. Z., Raichle M. E. Activation of extrastriate and frontal cortical areas by visual words and word-like stimuli. Science. 1990 Aug 31;249(4972):1041–1044. doi: 10.1126/science.2396097. [DOI] [PubMed] [Google Scholar]
  14. Petrides M., Alivisatos B., Evans A. C., Meyer E. Dissociation of human mid-dorsolateral from posterior dorsolateral frontal cortex in memory processing. Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):873–877. doi: 10.1073/pnas.90.3.873. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Petrides M., Alivisatos B., Meyer E., Evans A. C. Functional activation of the human frontal cortex during the performance of verbal working memory tasks. Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):878–882. doi: 10.1073/pnas.90.3.878. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Posner M. I., Petersen S. E., Fox P. T., Raichle M. E. Localization of cognitive operations in the human brain. Science. 1988 Jun 17;240(4859):1627–1631. doi: 10.1126/science.3289116. [DOI] [PubMed] [Google Scholar]
  17. Shimamura A. P., Janowsky J. S., Squire L. R. Memory for the temporal order of events in patients with frontal lobe lesions and amnesic patients. Neuropsychologia. 1990;28(8):803–813. doi: 10.1016/0028-3932(90)90004-8. [DOI] [PubMed] [Google Scholar]
  18. Squire L. R., Ojemann J. G., Miezin F. M., Petersen S. E., Videen T. O., Raichle M. E. Activation of the hippocampus in normal humans: a functional anatomical study of memory. Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1837–1841. doi: 10.1073/pnas.89.5.1837. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tulving E., Kapur S., Markowitsch H. J., Craik F. I., Habib R., Houle S. Neuroanatomical correlates of retrieval in episodic memory: auditory sentence recognition. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2012–2015. doi: 10.1073/pnas.91.6.2012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Warrington E. K., Weiskrantz L. Amnesia: a disconnection syndrome? Neuropsychologia. 1982;20(3):233–248. doi: 10.1016/0028-3932(82)90099-9. [DOI] [PubMed] [Google Scholar]
  21. Wise R., Chollet F., Hadar U., Friston K., Hoffner E., Frackowiak R. Distribution of cortical neural networks involved in word comprehension and word retrieval. Brain. 1991 Aug;114(Pt 4):1803–1817. doi: 10.1093/brain/114.4.1803. [DOI] [PubMed] [Google Scholar]
  22. Zatorre R. J., Jones-Gotman M., Evans A. C., Meyer E. Functional localization and lateralization of human olfactory cortex. Nature. 1992 Nov 26;360(6402):339–340. doi: 10.1038/360339a0. [DOI] [PubMed] [Google Scholar]

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