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. 1973 Feb;70(2):526–530. doi: 10.1073/pnas.70.2.526

Radioimmunoassay for Human Alpha1-Fetoprotein

Hulbert K B Silver 1,2, Phil Gold 1,2, Stephen Feder 1,2, Samuel O Freedman 1,2, Joseph Shuster 1,2
PMCID: PMC433297  PMID: 4119791

Abstract

A method of radioimmunoassay has been developed for the quantitation of alpha1-fetoprotein in human serum. The assay requires 20 μl of serum, can be completed in 8 hr, and can reproducibly detect concentrations of 20 ng of alpha1-fetoprotein per ml of serum. Hence, the method is about 500-fold more sensitive for the detection of alpha1-fetoprotein than the Ouchterlony teohnique currently in general use. The procedure is of potential clinical value as an aid in the diagnosis of cancer and a number of noncancerous hepatic diseases.

Keywords: cancer, diagnosis, hepatoma, hepatitis, embryonic

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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