Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1973 Jul;70(7):2051–2054. doi: 10.1073/pnas.70.7.2051

A Tumor-Associated Antigen in Human Nephroblastomas

P Burtin 1, M C Gendron 1
PMCID: PMC433663  PMID: 4352967

Abstract

Antisera prepared against extracts of human nephroblastomas (Wilms' tumors) allowed the characterization in these extracts, and in a few extracts of tumors of other organs, of a tumor-associated antigen. This antigen is different from all previously described antigens, and was named W antigen (W for Wilms). It does not seem to be a carcinoembryonic antigen, and hence it could be of viral origin.

Keywords: Wilms' tumor, virus, immunoelectrophoresis, immunofluorescence

Full text

PDF
2053

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABELEV G. I. Study of the antigenic structure of tumors. Acta Unio Int Contra Cancrum. 1963;19:80–82. [PubMed] [Google Scholar]
  2. Allerton S. E., Beierle J. W., Powars D. R., Bavetta L. A. Abnormal extracellular components in Wilms' tumor. Cancer Res. 1970 Mar;30(3):679–683. [PubMed] [Google Scholar]
  3. Burtin P., Sabine M. C. Inhibition of the non-specific fixation of fluorescent globulins. Rev Eur Etud Clin Biol. 1972 Jan;17(1):76–77. [PubMed] [Google Scholar]
  4. Diehl V., Jereb B., Stjernswärd J., O'Toole C., Ahström L. Cellular immunity to nephroblastoma. Int J Cancer. 1971 Mar 15;7(2):277–284. doi: 10.1002/ijc.2910070212. [DOI] [PubMed] [Google Scholar]
  5. Druet P., Burtin P. Mise en evidence dans les cancers renaux d'un antigène non présent dans le rein normal. Eur J Cancer. 1967 Aug;3(3):237–238. doi: 10.1016/0014-2964(67)90050-3. [DOI] [PubMed] [Google Scholar]
  6. Edynak E. M., Old L. J., Vrana M., Lardis M. P. A fetal antigen associated with human neoplasia. N Engl J Med. 1972 Jun 1;286(22):1178–1183. doi: 10.1056/NEJM197206012862203. [DOI] [PubMed] [Google Scholar]
  7. Gold P., Freedman S. O. Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 1965 Sep 1;122(3):467–481. doi: 10.1084/jem.122.3.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Häkkinen I. P. An immunochemical method for detecting carcinomatous secretion from human gastric juice. Scand J Gastroenterol. 1966;1(1):28–32. doi: 10.1080/00365521.1966.11800610. [DOI] [PubMed] [Google Scholar]
  9. Linder E. The antigenic structure of nephroblastomas. Int J Cancer. 1969 Mar 15;4(2):232–247. doi: 10.1002/ijc.2910040214. [DOI] [PubMed] [Google Scholar]
  10. TATARINOV Iu S. OBNARUZHENIE EMBRIOSPETSIFICHESKOGO ALPHA-GLOBULINA V SYVOROTKE KROVI BOL'NOGO PERVICHNYM RAKOM PECHENI. Vopr Med Khim. 1964 Jan-Feb;10:90–91. [PubMed] [Google Scholar]
  11. Trouillas P. Immunologie des tumeurs cérébrales: l'antigène carcino-foetal glial. Ann Inst Pasteur (Paris) 1972 Apr;122(4):819–828. [PubMed] [Google Scholar]
  12. von Kleist S., Burtin P. Isolation of a fetal antigen from human colonic tumors. Cancer Res. 1969 Nov;29(11):1961–1964. [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES