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. 1973 Jul;70(7):2139–2144. doi: 10.1073/pnas.70.7.2139

Discrimination between Messenger Ribonucleic Acids by a Mammalian Translation Initiation Factor

U Nudel 1, B Lebleu 1, M Revel 1
PMCID: PMC433683  PMID: 4352974

Abstract

A factor from rabbit-reticulocyte ribosome, which stimulates by 5-fold initiation of hemoglobin mRNA translation in Krebs ascites cell extracts, was purified to homogeneity. The factor, a protein of about 65,000 molecular weight in sodium dodecyl sulfate, discriminates between various mRNAs: it stimulates translation of α globin mRNA and of tobacco mosaic virus RNA, but has only a small effect on β globin mRNA and no effect at all on Mengo virus RNA translation.

Keywords: reticulocyte initiation factors, hemoglobin synthesis, Krebs ascites extracts

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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