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. 1973 Aug;70(8):2335–2339. doi: 10.1073/pnas.70.8.2335

Nucleotide Sequences from Tryptophan Messenger RNA of Escherichia coli: The Sequence Corresponding to the Amino-Terminal Region of the First Polypeptide Specified by the Operon

Morley J Bronson 1, Craig Squires 1, Charles Yanofsky 1
PMCID: PMC433730  PMID: 4599621

Abstract

Mutants with internal deletions that terminate near the operator end of the tryptophan operon of E. coli were used in studies on the nucleotide sequence at the 5′ end of the messenger RNA transcribed on this operon. The findings obtained permitted identification of a sequence of 43 nucleotides corresponding to the aminoterminal 11 amino acids of anthranilate synthetase component I, the polypeptide specified by the operator-proximal structural gene of the operon. It was also shown that the translation initiation codon for this polypeptide is preceded on the messenger by a “leader” sequence of unknown function, at least 150 nucleotides in length.

Keywords: anthranilate synthetase component I, tryptophan operon

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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