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. 1974 Sep;71(9):3588–3592. doi: 10.1073/pnas.71.9.3588

Genetic Control of Basal Serum Immunoglobulin E Level and Its Effect on Specific Reaginic Sensitivity*

David G Marsh †,‡, Wilma B Bias §, Kimishige Ishizaka
PMCID: PMC433820  PMID: 4139719

Abstract

Studies of the distribution of total serum immunoglobulin E levels in nonallergic and allergic populations defined a cut-off point between low and high immunoglobulin E at 95 U/ml, based on Mendelian recessive inheritance of high immunoglobulin E level. Subsequent investigations of the distribution of total serum immunoglobulin E levels in 28 allergic families confirmed the recessive hypothesis. The results of quantitative skin tests in eight families, performed with between five and eight highly purified grass and ragweed pollen allergens per family, demonstrate that the immunoglobulin E-regulating gene exerts a profound effect on specific immunoglobulin E-mediated sensitivity, often masking the effect of HL-A associated immune response genes.

Keywords: regulator gene, Ir genes, HL-A antigens, allergens, atopy

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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